Actively Recruiting
Impact of Cognitive-Motor Incorporated Training and Brain Activation Patterns in Cerebrovascular Diseases With Cognitive and Motor Impairments: Post Stroke Cognitive Impairment and Moyamoya Disease
Led by National Taiwan University Hospital · Updated on 2026-01-30
210
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the impact of motor-cognitive incorporated training (MCIT) on individuals with post-stroke cognitive impairment (PSCI) or Moyamoya disease (MMD). The study explores the relationship between cognitive and motor impairments and brain activation patterns using functional near-infrared spectroscopy (fNIRS). It includes a cross-sectional comparison with healthy controls and randomized controlled trials to assess training effects. The study has three parts: Part I characterizes cognitive and motor performance and brain activation in PSCI, MMD, and healthy adults. Parts II and III are single-blinded randomized controlled trials testing the short- and long-term effects of MCIT versus motor training alone in people with PSCI or MMD. Training sessions last 30 minutes, three times per week, for four weeks. MCIT combines motor and cognitive tasks, while the control group receives motor training only. Participants undergo baseline assessments of cognition, motor function, and brain activity, followed by post-intervention and follow-up tests at 1, 3, and 12 months. Assessments include global cognition, executive function, sensorimotor tests, muscle strength, and ambulation. Brain activation is measured during tasks with fNIRS. Follow-up may include telephone interviews focusing on return-to-work status. The total participation spans from initial screening through one year post-intervention.
CONDITIONS
Brief Title
Cognitive-Motor Incorporated Training and Its Relations in Cerebrovascular Diseases With Cognitive and Motor Impairments
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 20 years or older
- Ability to stand for more than 30 seconds
- For healthy controls: Montreal Cognitive Assessment (MoCA) score higher than 26
- For post-stroke cognitive impairment (PSCI) group: diagnosis of stroke confirmed by brain CT or MRI, symptom onset more than 7 days prior, MoCA score less than 26
- For Moyamoya disease (MMD) group: confirmed diagnosis through CT scan or angiography, subacute phase if stroke occurred (one week post-stroke), MoCA score less than 26
You will not qualify if you...
- Unstable or uncontrolled vital signs (resting heart rate >100 or <40 BPM, respiratory rate >20 or <12 breaths per minute, SpO2 <95%, central arterial pressure <80 mmHg)
- Need for intracranial pressure (ICP) monitoring
- Requirement for invasive mechanical ventilation or deemed unsuitable by physician due to unstable medical conditions
- Presence of other neurological disorders or unstable conditions interfering with the study
- Currently hospitalized in intensive care unit (ICU)
- Severe visual or hearing impairments, or communication and comprehension difficulties interfering with participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 5 weeks
Participants undergo either the Motor-Cognitive Incorporated Training (MCIT) program or a motor training program to improve cognitive and motor outcomes. Training includes motor exercises and cognitive tasks with increasing difficulty based on participant progress.
Multiple visits during the 5-week training period
Duration - 12 weeks post-intervention
Participants are assessed for cognitive and motor function to evaluate the short- and long-term effects of the training programs after the intervention ends.
3 visits (immediately post-intervention, 4 weeks post-intervention, and 12 weeks post-intervention)
Trial Site Locations
Total: 1 location
1
National Taiwan University
Taipei, Taiwan
Actively Recruiting
Research Team
Y
Yan Ci Liu, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
7
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