Evaluating Motor-Cognitive Training and Brain Activity in Adults with Post-Stroke Cognitive Impairment or Moyamoya Disease

What this Trial Is About

Researchers are studying the impact of motor-cognitive incorporated training MCIT on individuals with post-stroke cognitive impairment PSCI or Moyamoya disease MMD. The study explores the relationship between cognitive and motor impairments and brain activation patterns using functional near-infrared spectroscopy fNIRS. It includes a cross-sectional comparison with healthy controls and randomized controlled trials to assess training effects. The study has three parts Part I characterizes cognitive and motor performance and brain activation in PSCI, MMD, and healthy adults. Parts II and III are single-blinded randomized controlled trials testing the short- and long-term effects of MCIT versus motor training alone in people with PSCI or MMD. Training sessions last 30 minutes, three times per week, for four weeks. MCIT combines motor and cognitive tasks, while the control group receives motor training only. Participants undergo baseline assessments of cognition, motor function, and brain activity, followed by post-intervention and follow-up tests at 1, 3, and 12 months. Assessments include global cognition, executive function, sensorimotor tests, muscle strength, and ambulation. Brain activation is measured during tasks with fNIRS. Follow-up may include telephone interviews focusing on return-to-work status. The total participation spans from initial screening through one year post-intervention.

Cognitive-Motor Incorporated Training and Its Relations in Cerebrovascular Diseases With Cognitive and Motor Impairments