Actively Recruiting
Cognitive-motor Telerehabilitation in MS
Led by Universitair Ziekenhuis Brussel · Updated on 2026-05-08
90
Participants Needed
2
Research Sites
260 weeks
Total Duration
On this page
Sponsors
U
Universitair Ziekenhuis Brussel
Lead Sponsor
N
National MS Center Melsbroek
Collaborating Sponsor
AI-Summary
What this Trial Is About
The primary goal of this project is providing evidence that a home-based combined cognitive-motor training program improves cognition in persons with multiple sclerosis (MS), compared to single cognitive and motor rehabilitation. Secondary goals are to assess the effects on walking performance and to identify the mechanisms of improvement and predictors of treatment response. The main backbone of this project will be a randomized controlled two-centre clinical trial, in which an at-home computerised cognitive-motor rehabilitation program using telemedicine aimed at improving working memory in persons with MS will be evaluated. Based on the information gathered during this trial, possible mechanisms of improvement will be identified by analysing anatomical and neurophysiological changes on structural MRI and resting-state and task-related EEG before and after rehabilitation. Furthermore, factors that can predict treatment response to the rehabilitation program will be identified.
CONDITIONS
Official Title
Cognitive-motor Telerehabilitation in MS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinically definite multiple sclerosis diagnosed by revised McDonald criteria 2017
- Expanded Disability Status Scale (EDSS) score below 6.0
- Digit span backwards z-score between -3 and -0.5 standard deviations below the median of normative values
- Age between 18 and 65 years
- Ability to safely perform motor rehabilitation at home, confirmed by a rehabilitation physician or therapist
You will not qualify if you...
- Received cognitive rehabilitation within six months before joining
- Participated in or planned an inpatient multidisciplinary rehabilitation program within three months before or during the trial
- Started or switched immunomodulator treatment within three months before joining
- Less than one month since an MS exacerbation
- Major psychiatric or medical disorder affecting cognitive functions
- Vision worse than 0.6 on Snellen Visual Acuity Test even with correction
- Unable or unwilling to undergo EEG or MRI scans
- Refusal to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Universitair Ziekenhuis Brussel
Brussels, Belgium
Actively Recruiting
2
National MS Center Melsbroek
Melsbroek, Belgium
Actively Recruiting
Research Team
D
Delphine Van Laethem
CONTACT
G
Guy Nagels
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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