Home-Based Combined Cognitive and Motor Training to Improve Thinking and Walking in Adults with Multiple Sclerosis Aged 18 to 65

What this Trial Is About

Researchers are evaluating a home-based combined cognitive and motor training program to improve cognition in people with multiple sclerosis MS. This randomized controlled clinical trial aims to compare this combined program to cognitive training alone and motor training alone. The study also explores how these treatments affect walking performance and seeks to identify mechanisms of improvement and predictors of treatment response using brain imaging and electrical activity measurements. Participants will be randomly assigned to one of three groups a combined cognitive-motor training group, a cognitive training group, or a motor training group. The cognitive training uses a computer program called RehaCom focused on working memory with sessions lasting 45 minutes, one to two days per week for 12 weeks. The motor training involves a personalized aerobic exercise program at home, with exercise intensity tracked by a sport watch and lasting 90 minutes for the motor group and 45 minutes for the combined group, divided into sessions of at least 15 minutes twice a week. During the study, participants will undergo assessments at several time points baseline, 12 weeks, 24 weeks, and 64 weeks. These assessments include cognitive tests like the Digit Span Backwards, physical tests such as the 6-Minute Walk Test, and brain imaging including MRI and EEG. Researchers will monitor changes in cognition, disability status, walking ability, and brain function. The study will last over a year, allowing long-term follow-up of effects and safety.

Cognitive-motor Telerehabilitation in MS