Actively Recruiting
Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients
Led by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Updated on 2025-07-01
338
Participants Needed
2
Research Sites
654 weeks
Total Duration
On this page
Sponsors
S
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Lead Sponsor
U
United States Department of Defense
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this trial is to determine whether it is possible to minimize radiation dose to parts of the brain that are important for thinking and learning in children who require radiation to treat their tumor, and if this will help reduce neurocognitive (thinking and learning) impairments in these patients. Patients with newly diagnosed brain or head and neck tumors who are having radiation therapy will have neurocognitive testing and MRI imaging (both research and for regular care) done as part of their participation in the study. Survivors of childhood brain tumors who completed radiation therapy at least two years before joining the study, and have not had a recurrence, will have neurocognitive testing and research MRIs completed. Healthy children will also be enrolled and have research MRIs done. The researchers will use the radiation plan to determine how much radiation was delivered to different parts of the brain. The investigators will use the MRIs to determine how the normal brain is changing after treatment; and how this compares to patients who had standard radiation treatment or who never had a brain tumor. The neurocognitive testing will be compared among different groups to see how different treatment plans affect performance on neurocognitive tests.
CONDITIONS
Official Title
Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 1 to less than 26 years
- Tumor located in the brain or adjacent areas including nasopharynx, paranasal sinuses, or orbit
- Treatment includes radiation therapy (proton or photon)
- Patients must not have completed radiation therapy
- Diagnosed with a brain tumor before 26 years of age
- Received radiation to the brain as part of therapy
- At least 2 years have passed since radiation start to study enrollment
- No disease recurrence since most recent radiation treatment
- Aged 5 to less than 26 years
- Able to complete research imaging without sedation
You will not qualify if you...
- Pregnancy
- Unable to undergo neurocognitive testing, including lack of English comprehension or premorbid neurological/neurodevelopmental disorders such as Down's syndrome or autism
- Major psychiatric, neurologic, or medical diagnosis
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Sibley Memorial Hospital
Washington D.C., District of Columbia, United States, 20016
Actively Recruiting
2
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287
Actively Recruiting
Research Team
S
Sahaja Acharya, MD
CONTACT
K
Katie Lowe
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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