Actively Recruiting
Cognitive Reappraisal Training for Borderline Personality (BPD)
Led by Icahn School of Medicine at Mount Sinai · Updated on 2025-12-03
130
Participants Needed
1
Research Sites
141 weeks
Total Duration
On this page
Sponsors
I
Icahn School of Medicine at Mount Sinai
Lead Sponsor
W
William Marsh Rice University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Previous work by the group convinced the researchers to pursue development of focused cognitive reappraisal training as a novel approach to treatment of BPD, either as stand-alone treatment or in concert with evidence-based treatments of BPD. The present proposal aims to refine and test a proposed clinical intervention for BPD patients, training in reappraisal-by-distancing, in terms of its ability to influence hypothesized neural and behavioral targets and, once that is established, to demonstrate its ability improve clinically relevant outcome measures.
CONDITIONS
Official Title
Cognitive Reappraisal Training for Borderline Personality (BPD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Medically healthy men and women with Borderline Personality Disorder who are mentally competent and give informed voluntary written consent.
- Participants will be between the ages of 18 and 55.
- Inclusion includes both genders and all racial/ethnic groups to reflect previous recruitment.
- Participants with comorbid avoidant personality disorder are included.
- Participants with PTSD are included if they are not actively experiencing symptoms.
You will not qualify if you...
- Participants meeting criteria for Schizotypal Personality Disorder are excluded.
- Participants currently meeting criteria for Major Depressive Disorder are excluded.
- Participants meeting criteria for present PTSD, bipolar I disorder, schizophrenia, schizoaffective disorder, substance use disorder within the past 6 months, organic mental syndromes, head trauma, schizotypal personality disorder, CNS neurological disease, or seizure disorder are excluded.
- Participants with substance use disorder more than 6 months prior to enrollment may be included.
- Participants with pacemakers, surgical clips, metallic implants, or shrapnel fragments contraindicating MRI are excluded.
- Pregnant women are excluded.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Actively Recruiting
Research Team
H
Harold W Koenigsberg, MD
CONTACT
B
Brian B Kang, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here