Study of Modafinil Effects on Decision Making and Brain Activity in Adults Aged 18 to 35

What this Trial Is About

Researchers are studying decision making in psychosis spectrum disorders, such as schizophrenia, by evaluating how a single dose of modafinil affects brain activity and performance on brain games. This study aims to improve understanding of psychosis to help future patients. It is a phase 3 interventional trial involving healthy participants aged 18 to 35. Participants will attend two appointments about one week apart. The first visit includes an interview, questionnaires, and brain games on a computer. The second visit involves safety screening, wearing an EEG cap to measure brain activity, playing brain games before and after taking a single 200mg dose of modafinil, and monitoring vital signs. Participants will also receive a meal during the modafinil metabolism period and be contacted by phone the next day for follow-up on any side effects. During the study, participants complete interviews about their medical and psychiatric history and quality of life. Assessments include blood draws, urine drug and pregnancy tests, alcohol breathalyzer, and EEG recordings. Outcome measures focus on performance changes in various brain games and brain activity via EEG. Safety is monitored through vital signs and follow-up calls. Total participation involves two visits and a phone call, with tasks lasting from 30 minutes up to 4.5 hours per session.

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