Actively Recruiting
Cognitive Strategies for Optimizing Brain Health And Managing Transgenerational Vascular Risk Factors Post-Stroke (CHAMPS for Transgenerational Risk)
Led by University of New Mexico · Updated on 2026-02-11
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a virtual program called CHAMPS for Transgenerational Risk (CHAMPS-TR) aimed at reducing stroke risk and improving brain health in people who have had an ischemic stroke and their biological family members. This study focuses on addressing cognitive effects of stroke and the increased risk of stroke and cognitive decline that can run in families. The program offers a chance for families to engage in preventative care through a remotely delivered intervention. Participants include persons with stroke and a targeted family member, who will receive vascular risk reduction coaching and cognitive strategy training via 10 virtual sessions over 5 weeks. Some participants with stroke may also receive remotely supervised transcranial Direct Current Stimulation (RS-tDCS) five times weekly during weeks 2 to 5 to potentially enhance cognitive benefits. This minimally invasive brain stimulation is delivered remotely and aims to support the cognitive training. Participants will undergo assessments at the start, around 7 weeks, and up to 24 weeks later, including measures of cardiovascular risk factors and cognitive tests such as the Oral Trail Making Test and Number Span Test. Researchers will monitor adherence and evaluate changes in brain health and vascular risk. The study is designed to be accessible virtually to accommodate participants with mobility challenges, with the total involvement lasting about 24 weeks.
CONDITIONS
Brief Title
Cognitive Strategies for Optimizing Brain Health And Managing Transgenerational Vascular Risk Factors Post-Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Primary diagnosis of acute ischemic stroke
- Cognitive impairment indicated by a score greater than 1 on the Quick Executive Interview telephone screener
- No severe aphasia (score of 0 or 1 on NIH Stroke Scale)
- No pre-stroke dementia (client report)
- No major anxiety or depressive disorder based on PHQ-9 and GAD-7
- No drug or alcohol misuse in the past 3 months (AUDIT, DAST)
- Age greater than 40 years
- Having a potential family member who meets targeted family member criteria
- Eligible for MRI and Remote Supervised-transcranial direct current stimulation if assigned to that intervention
- Targeted family member must be biological kin, at least 18 years old, without dementia or major anxiety/depression, no recent substance misuse, and have a sibling or parent who had an ischemic stroke
You will not qualify if you...
- Not English speaking or unable to read and understand English
- No access to video-conference software on a computer or smart device
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (virtual)
Duration - 5 weeks
Participants receive the CHAMPS-TR intervention which includes vascular risk reduction coaching and metacognitive problem-solving training delivered virtually. Participants in one arm also receive remotely supervised transcranial Direct Current Stimulation (RS-tDCS) applied 5 times weekly during weeks 2 to 5.
10 virtual intervention sessions (bi-weekly for 5 weeks), plus 5 weekly RS-tDCS sessions during weeks 2 to 5 for eligible participants
Duration - Up to 19 weeks after treatment
Participants are monitored up to 24 weeks after baseline to assess cognitive and vascular health outcomes.
Assessments at baseline, up to 7 weeks, and up to 24 weeks
Trial Site Locations
Total: 1 location
1
University of New Mexico Health Sciences Center
Albuquerque, New Mexico, United States, 87131
Actively Recruiting
Research Team
S
Suzanne Burns, PhD
T
Tim Dionne, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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