Actively Recruiting
Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors
Led by St. Jude Children's Research Hospital · Updated on 2026-04-23
45
Participants Needed
1
Research Sites
192 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this study is to estimate the feasibility and acceptability of cognitive training in the virtual reality setting with children undergoing radiotherapy for brain tumors. To achieve this goal, the investigators plan to study children undergoing radiotherapy for brain tumors randomly assigned to cognitive training administered via an iPad or virtual reality. Both groups will also participate in cognitive testing and exams using functional near infrared spectroscopy (fNIRS) pre- and post-intervention. The questions to be investigated are: 1. Will cognitive training via virtual reality be feasible and acceptable for children undergoing radiotherapy for brain tumors as indicated by participation rates, adherence and frequency of side effects? 2. Will cognitive training via virtual reality provide neurocognitive benefits? 3. Will there be predictable changes in brain activity as measured by neuroimaging? Findings from this study will be used to develop a larger, definitive trial with direct potential to improve cognitive outcomes for children treated for cancer using a safe and effective alternative to desktop- or laptop-based computerized cognitive interventions with great promise for improving quality of life.
CONDITIONS
Official Title
Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Initiating radiotherapy for a brain tumor
- Between 8 and 22 years of age at enrollment
- English or Spanish as the primary language
- Participant and one parent willing to participate and provide consent/assent
- Participant willing to take part in required cognitive training sessions
You will not qualify if you...
- Significant intellectual impairment with IQ below 70
- History of serious neurological disease before brain tumor diagnosis, such as stroke or head injury with loss of consciousness
- Major sensory or motor impairment preventing valid cognitive testing (e.g., blindness, paralysis, poorly controlled seizures, inability to balance to complete training)
- Psychiatric conditions that prevent or take precedence over study participation (e.g., active psychosis, suicidal thoughts)
- Need for general anesthesia during radiation therapy (participation allowed if only sedated for planning but not daily treatment)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
Research Team
H
Heather Conklin, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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