Actively Recruiting
Cognitive and Vascular Functioning Following TBI
Led by Walter Reed National Military Medical Center · Updated on 2025-09-26
300
Participants Needed
1
Research Sites
178 weeks
Total Duration
On this page
Sponsors
W
Walter Reed National Military Medical Center
Lead Sponsor
J
Johns Hopkins University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This observational study will examine the association of chronic traumatic cerebrovascular injury and cardiovascular risk factors with TBI-related cognitive impairment and vascular dementia. Cerebrovascular, inflammatory, and neurodegenerative blood biomarkers as well as clinical and neuroimaging data
CONDITIONS
Official Title
Cognitive and Vascular Functioning Following TBI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Active duty Service Member or Veteran currently eligible for treatment at WRNMMC
- Ability to read, write, and speak English
- Ability to provide informed consent
- Participation in NICoE Intensive Outpatient Program or NatHx Study comprehensive evaluation at least 3 years prior with valid neuropsychological test results
- Consent to access prior research data and at least one prior blood specimen from NICoE, NatHx Study, or DoD Serum Biorepository
- History of at least one mild, moderate, severe, or penetrating TBI more than 3 years ago, confirmed by loss of consciousness, post-traumatic amnesia, alteration of consciousness, neurologic dysfunction, or TBI-related abnormality on brain imaging
- For additional control groups: history of military deployment with low blast exposure (<10 blasts) or significant blast exposure (≥10 blasts)
You will not qualify if you...
- Disabling neurological or psychological disorders such as autism, cerebral palsy, developmental disorder, stroke, brain tumor, multiple sclerosis, meningitis, encephalitis, brain abscess, vascular malformation, pre-injury epilepsy, schizophrenia, bipolar disorder, or personality disorder
- Diabetes requiring drug treatment
- Hypertension requiring more than one antihypertensive medication
- History of myocardial infarction or other systemic vascular diseases
- Diagnosis of dementia at initial NICoE or NatHx Study assessment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Walter Reed National Military Medical Center
Bethesda, Maryland, United States, 20889
Actively Recruiting
Research Team
S
Sara M Lippa, PhD
CONTACT
M
Megan E Glazer, M.S.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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