Actively Recruiting
CogT pSOPT Intervention Study
Led by Stanford University · Updated on 2024-05-17
50
Participants Needed
1
Research Sites
154 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
(JUSTIFICATION: This is the R33 stage of an NIH funded R21/R33 study. R21 stage (IRB-61727) was focused on intervention development; R33 stage will focus on pilot testing the effect of the intervention. The R21 phase was not considered a NIH defined clinical trial; R33 will be considered a NIH defined clinical trial) The purpose is to develop and test the effect of a "personalized" computer-based cognitive training program. The personalized program tailors the difficulty of the training tasks using a participant's biofeedback (i.e., heart rate) and cognitive performance. Such a personalization will ensure that the participant can perform at his/her ideal training capacity. Participants will be randomized into one of 2 groups and each group will play a different version of computerized training game and have ECG collected to allow subject blinding.
CONDITIONS
Official Title
CogT pSOPT Intervention Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presence of memory complaint
- Rey Auditory Verbal Learning Test delayed recall less than 59% of age-adjusted norm
- Montreal Cognitive Assessment score between 18 and 27
- Functional Assessment Questionnaire score less than 20
- Intact score on San Diego Brief Assessment of Capacity to Consent (UBACC)
- Stable dose for 3 months prior to recruitment if on Alzheimer's disease medication, antidepressants, anxiolytics, or vascular-related medications
- Age 60 years or older
- Able to read and understand English
- Adequate visual and hearing acuity by self-report
- Living independently in the community
You will not qualify if you...
- Currently enrolled in another cognitive improvement study
- Uncontrollable major depression
- Major cerebrovascular or cardiovascular diseases such as congestive heart failure, pacemaker, or prior myocardial infarction
- Having an active legal guardian indicating impaired decision-making capacity
- Currently pregnant
- Contraindications for 3T MRI
- Diagnosed neurodegenerative diseases such as Parkinson's, Alzheimer's, dementia, or multiple sclerosis
- Other neurological conditions like stroke, seizures, or traumatic brain injury will be evaluated case-by-case based on severity and recovery
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
CogT Lab, Stanford University
Palo Alto, California, United States, 94304-0000
Actively Recruiting
Research Team
F
Feng Lin, BS
CONTACT
S
Sarah Therrien
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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