Actively Recruiting
Personalized Engine for Speed of Information Processing Cognitive Training for Mild Cognitive Impairment
Led by Stanford University · Updated on 2024-05-17
50
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a personalized computer-based cognitive training program aimed at older adults with mild or subjective cognitive impairment. This study focuses on testing the effects of tailoring training difficulty using a participant's heart rate and cognitive performance to optimize training capacity. The study is a randomized, double-blind trial funded by NIH and led by Stanford University. Participants will be assigned randomly to one of two groups: one group will use the personalized speed of processing training (pSOPT) where task difficulty adjusts based on real-time parasympathetic nervous system signals captured through ECG. The other group will engage in computerized mental leisure activities such as crossword puzzles, Sudoku, and solitaire, also while having ECG monitoring to maintain blinding. During the study, participants will be assessed at baseline, week 7, and three months using a composite cognitive measure to evaluate changes in cognition. Additionally, researchers will monitor the functional integrity of the central autonomic network. Participants will complete questionnaires and cognitive tests while ECG data is collected to help tailor the intervention and ensure safety. The total study period includes initial screening and follow-up assessments over a few months.
CONDITIONS
Brief Title
CogT pSOPT Intervention Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Memory complaint present
- Rey Auditory Verbal Learning Test delayed recall below 59% of age-adjusted norm
- Montreal Cognitive Assessment score between 18 and 27
- Functional Assessment Questionnaire score below 20
- Intact capacity to consent as measured by San Diego Brief Assessment of Capacity to Consent
- Stable dose of Alzheimer's, antidepressant, anxiolytic, or vascular medications for at least 3 months prior
- Age 60 years or older
- Able to read and understand English
- Adequate vision and hearing by self-report
- Living independently in the community
You will not qualify if you...
- Currently enrolled in another cognitive improvement study
- Uncontrolled major depression
- Major cerebrovascular or cardiovascular disease such as congestive heart failure, pacemaker, or prior heart attack
- Having an active legal guardian indicating impaired decision-making capacity
- Currently pregnant
- Contraindication for 3T MRI
- Diagnosed neurodegenerative diseases including Parkinson's, Alzheimer's, dementia, or multiple sclerosis
- Other neurological conditions like stroke, seizures, or traumatic brain injury will be evaluated individually based on severity and recovery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 7 weeks
Participants undergo computerized cognitive training or mental leisure activities to practice speed of processing or engage in mental exercises.
Weekly visits for up to 7 weeks
Duration - 3 months
Participants are monitored for cognitive changes and autonomic function after the intervention ends.
1 visit at 3 months post-treatment
Trial Site Locations
Total: 1 location
1
CogT Lab, Stanford University
Palo Alto, California, United States, 94304-0000
Actively Recruiting
Research Team
F
Feng Lin, BS
S
Sarah Therrien
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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