Study of Personalized Computer-Based Cognitive Training to Improve Information Processing Speed in Older Adults with Mild or Subjective Cognitive Impairment

What this Trial Is About

Researchers are evaluating a personalized computer-based cognitive training program aimed at older adults with mild or subjective cognitive impairment. This study focuses on testing the effects of tailoring training difficulty using a participants heart rate and cognitive performance to optimize training capacity. The study is a randomized, double-blind trial funded by NIH and led by Stanford University. Participants will be assigned randomly to one of two groups one group will use the personalized speed of processing training pSOPT where task difficulty adjusts based on real-time parasympathetic nervous system signals captured through ECG. The other group will engage in computerized mental leisure activities such as crossword puzzles, Sudoku, and solitaire, also while having ECG monitoring to maintain blinding. During the study, participants will be assessed at baseline, week 7, and three months using a composite cognitive measure to evaluate changes in cognition. Additionally, researchers will monitor the functional integrity of the central autonomic network. Participants will complete questionnaires and cognitive tests while ECG data is collected to help tailor the intervention and ensure safety. The total study period includes initial screening and follow-up assessments over a few months.

CogT pSOPT Intervention Study