Actively Recruiting
Observational Study to Identify Blood and EEG Biomarkers for Neurosyphilis in Adults Aged 18-65
Led by Shanghai Mental Health Center · Updated on 2024-11-08
360
Participants Needed
1
Research Sites
26 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are conducting an observational study to identify diagnostic biomarkers for neurosyphilis by examining plasma biomarkers and electrophysiological characteristics, including EEG and eye movement. The study aims to understand which biomarkers and electrophysiological findings are linked to neurosyphilis and how these can assist in diagnosis. Participants include neurosyphilis patients, non-neurosyphilis syphilis patients, and healthy controls. They will provide clinical information such as age, gender, symptoms, and disease course. Blood and urine samples will be collected for proteomics and metagenomic sequencing, and EEG and eye movement evaluations will be performed for electrophysiological analysis. Participants will be assessed at baseline, 6 months, and 12 months for AIM2 inflammasome in blood and NFL and sTREM2 in cerebrospinal fluid. Cognitive function will also be evaluated at baseline and 6 months using the MoCA test. The study includes monitoring for safety and adherence to assessments over these time points.
CONDITIONS
Brief Title
Cohort-Based Study of Diagnostic Biomarkers for Neurosyphilis
Research Team
X
Xiaoyun Guo, PhD
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