Actively Recruiting
Cohort Biomonitoring Study to Evaluate the Biocompatibilty of Resin-based Dental Materials
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2024-07-03
100
Participants Needed
1
Research Sites
391 weeks
Total Duration
On this page
Sponsors
U
Universitaire Ziekenhuizen KU Leuven
Lead Sponsor
K
KU Leuven
Collaborating Sponsor
AI-Summary
What this Trial Is About
Adult patients who require multiple dental restorations will be included in this study. Urine and saliva samples will be taken for determination of bisphenol A levels at several time points, and for analysis of the estrogenic activity using ERE-CALUX. Also buccal cells will be taken. Next, DNA extraction will be done with a commercial kit. We will determine global alterations in DNA methylation and DNA hydroxymethylation levels using UPLC-MS/MS.
CONDITIONS
Official Title
Cohort Biomonitoring Study to Evaluate the Biocompatibilty of Resin-based Dental Materials
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Caucasian adults
You will not qualify if you...
- Acute or chronic medical condition
- Oral inflammatory conditions in the previous 2 weeks
- Chronic disease requiring medication
- Exposure to diagnostic X-rays in the previous 2 months
- Smoking
- Consumption of alcohol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
BIOMAT, Department of Oral Health Sciences
Leuven, Belgium, 3000
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
1
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