Actively Recruiting
Cohort Evaluation of Body Fluids Early Detection of Cancer in High-risk Individuals
Led by Gustave Roussy, Cancer Campus, Grand Paris · Updated on 2026-03-30
5909
Participants Needed
1
Research Sites
219 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
LEAH is a prospective, observational, single-centre, non-randomised, open-label study of people at increased risk of cancer or malignant disease. The main objective of LEAH is to evaluate and compare the sensitivity of different tests on body fluids to detect cancers that will occur within 3 years of inclusion in the study, in a cohort of individuals identified as being at increased risk of cancer.
CONDITIONS
Official Title
Cohort Evaluation of Body Fluids Early Detection of Cancer in High-risk Individuals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older
- Have a cumulative 3-year risk of developing any cancer of at least 4% based on specific genetic, personal, or family history factors
- Personal cancer or blood cancer history allowed if in complete remission for at least 5 years
- Understand spoken and written French
- Agree to follow the study protocol
- Able to provide informed consent
- Able to access internet via telephone or computer
- Control group: individuals diagnosed with benign conditions, aged over 18, not at high risk, meeting the same language and consent requirements
You will not qualify if you...
- Prior cancer or blood cancer diagnosis within the past 5 years except certain skin and cervical cancers and specific genetic cases
- Signs or symptoms of cancer at study entry
- Recent worsening of autoimmune disease requiring increased treatment within 14 days before enrollment
- Medical conditions likely to cause death within 3 years
- Physical or psychological conditions incompatible with study participation or follow-up
- Under legal guardianship or unable to consent
- Women with certain genetic risks considering mastectomy soon or younger than 40 years
- Blood transfusion received within 1 week before inclusion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Gustave Roussy
Villejuif, France, 94800
Actively Recruiting
Research Team
S
Suzette Delaloge, MD
CONTACT
A
Adeline Salasc, PharmD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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