A Cohort of Maternal Vascular Malperfusion-related FGR CoMVMFGR

Led by Shanghai First Maternity and Infant Hospital · Updated on 2024-06-07

500

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Based on a precise diagnostic standard process, through a multicenter study, we will establish a cohort focusing on placenta-mediated fetal growth restriction (FGR). Long-term follow-up will be conducted to seek predictive indicators for short-term and long-term adverse outcomes of maternal vascular malperfusion-related FGR (MVM-FGR).

CONDITIONS

Brief Title

A Cohort of Maternal Vascular Malperfusion-related FGR (CoMVMFGR)

Who Can Participate

Age: 18Years - 45Years

FEMALE

Eligibility Criteria

Inclusion Criteria:

1.Singleton pregnancy 2. diagnosed as FGR according the delphi consensus:

Early-onset FGR(<32 weeks) Estimated fetal weight (EFW) or abdominal circumference (AC) < 3rd; or EFW or AC < 10th, combined with abnormal doppler, including uterine artery pulsatility index(UtA PI) >95th percentile, umbilical artery pulsatility index(UA PI) >95th percentile； or umbilical artery absent end-diastolic flow (UA-AEDF) or umbilical artery reversed end-diastolic flow(UA-REDF).
Late-onset FGR(≥32 weeks) Estimated fetal weight (EFW) or abdominal circumference (AC) < 3rd; or >2 of the following 3 criteria:
- EFW or AC <10th percentile
- EFW or AC crossing percentiles>2 quartiles on growth percentiles
- CPR <5th percentile or UA-Pl>95th percentile 3.provision of signed written informed consent.

Exclusion Criteria:

Fetus with definitive genetic disorders related to FGR, fetus with confirmed intrauterine infection (CMV, syphilis and etc.), fetus with structural anomalies
Incomplete information or absence of informed consent

Research Team

Jianping Chen, Master

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