Actively Recruiting
Cohort of Patients with Alzheimer's Disease and Their Families.
Led by University Hospital, Toulouse · Updated on 2024-12-19
1000
Participants Needed
4
Research Sites
195 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Toulouse
Lead Sponsor
F
France Alzheimer
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is the pilot phase of a longitudinal observational cohort study. The study includes family clusters comprised of a patient with Alzheimer's disease, an informal caregiver and at least one first-degree relative of the patient. The family clusters will be followed-up in expert memory centers and online in order to study risk and prognostic factors (including blood-based biomarkers) in the first-degree relatives and patients, respectively, as well as caregiver health, difficulties and needs. This pilot study is performed to assess the feasibility of conducting a larger-scale study.
CONDITIONS
Official Title
Cohort of Patients with Alzheimer's Disease and Their Families.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Probable Alzheimer's disease diagnosed by clinical and biological criteria
- Mild to moderate Alzheimer's disease with MMSE score of 15 or higher
- Fluent in French to complete study questionnaires
- Agree to medical exams at baseline, 12 months, and 24 months
- Affiliated to French social security
- Provide written informed consent
- Caregiver assists patient at least 6 hours per week for last 6 months
- Caregiver aged 18 years or older
- Caregiver fluent in French
- Caregiver agrees to answer regular health questionnaires
- First-degree relative of an Alzheimer's patient
- First-degree relative aged 18 years or older
- First-degree relative fluent in French
- First-degree relative agrees to medical exams and regular questionnaires
- Familial cluster includes 2 to 5 people: either 1 patient and 1 first-degree relative who is also a caregiver, or 1 patient, 1 caregiver, and 1 to 3 first-degree relatives
You will not qualify if you...
- Alzheimer's patients with other brain disorders
- Alzheimer's patients with autosomal dominant form of disease
- Alzheimer's patients under legal protection measures
- Alzheimer's patients who are institutionalized
- Alzheimer's patients with life expectancy less than 2 years
- Caregivers under legal protection measures
- Caregivers diagnosed with major neurocognitive disorder
- First-degree relatives related to autosomal dominant dementia patient
- First-degree relatives who carry autosomal dominant dementia mutation
- First-degree relatives under legal protection measures
- First-degree relatives diagnosed with major neurocognitive disorder
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Hôpitaux Universitaires de Marseille Timone
France, Marseille, France, 13005
Actively Recruiting
2
CMRR Centre de Montpellier
Montpellier, France
Actively Recruiting
3
CMRR Centre de Rouen
Rouen, France
Actively Recruiting
4
CMRR - CRC Centre de Toulouse
Toulouse, France
Actively Recruiting
Research Team
S
Sandrine Andrieu, MD PhD
CONTACT
N
Nicola Coley, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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