Observational Study on Primary Hyperparathyroidism Outcomes Following Parathyroidectomy at Nantes University Hospital

What this Trial Is About

Primary hyperparathyroidism is a common endocrine disorder, and this research aims to observe outcomes related to its main treatment, parathyroidectomy. The study focuses on understanding how surgery affects cardiovascular, bone, kidney health, and quality of life among patients diagnosed with this condition. It is a prospective, observational cohort study conducted at Nantes University Hospital that includes all patients diagnosed with sporadic primary hyperparathyroidism. Participants are observed whether or not they undergo parathyroidectomy. The study collects clinical and biochemical data at the start and at 6, 12, 36, and 60 months. Blood samples are also collected to analyze biomarkers related to bone remodeling and cardiovascular risk. Data include demographic information, imaging exams before surgery, outcomes after surgery, and assessments of the disease and treatment impact on target organs and quality of life. During the study, participants undergo regular evaluations including clinical exams, blood tests, and questionnaires assessing quality of life. Researchers monitor changes in cardiovascular events, cholesterol levels, insulin resistance, arterial stiffness, bone density, and kidney function over time. The study also examines the economic impact of surgical management compared to monitoring, with follow-up lasting up to five years after surgery or inclusion.

Cohort Primary Hyperparathyroidism