Prospective Cohort Study of Patients With Prosthetic Joint Infection Monitoring Treatment Outcomes and Reinfection

What this Trial Is About

Researchers are studying prosthetic joint infections (PJI), which are infections occurring in people with hip, knee, or shoulder joint prostheses. These infections are complex and require different treatments depending on the infection type, bone condition, the infecting organism, and the patient's overall health. Managing PJI often involves surgery combined with long-term antibiotic therapy, but in patients at high surgical risk, prolonged antibiotic use without surgery may be used. This large, long-term observational study aims to better understand PJI management and outcomes. The study includes patients treated for PJI through various surgical approaches such as debridement-synovectomy for acute infections, one-stage or two-stage exchange arthroplasty for chronic infections, or complete prosthesis removal combined with antibiotic therapy. It also includes patients receiving prolonged suppressive antibiotic therapy without surgery. The study follows participants for at least two years, collecting data for up to ten years, with enrollment over four years and up to six years of data collection. Participants are monitored regularly for reinfections, joint mechanical failure, and survival outcomes related to PJI. Assessments include joint function evaluations at one, two, four, and six years after prosthesis revision surgery, and tracking treatment outcomes for those on prolonged antibiotic therapy. The main outcome measured is the number of reinfections within two years, along with analysis of risk factors. This long-term follow-up allows researchers to evaluate the effectiveness and challenges of different PJI management strategies.

Cohort of Prosthetic Joint Infections