Longitudinal Study of Clinical and Imaging Features in Adults with Cerebral Small Vessel Disease Tracking Cognitive and Emotional Changes and Risk Factors

What this Trial Is About

Researchers are conducting a cohort study to observe patients with cerebral small vessel disease CSVD, focusing on how their cognitive functions and emotional health change over time. The study aims to describe the clinical and imaging features of CSVD, identify new risk factors, and understand the links between clinical symptoms and imaging results. Additionally, it seeks to develop a prediction model for cognitive and mood disorders in CSVD patients. Participants will undergo various assessments including multimodal magnetic resonance imaging following established STRIVE criteria, blood pressure variability measurements, neuropsychological testing, and blood sample collection. An experienced radiologist and neurologist will jointly interpret imaging results. Data collection and follow-up will capture dynamic clinical and imaging changes during the study period. Participants will provide baseline demographic and clinical information and complete tests to assess cognition, mood, and blood pressure variability. The study will monitor changes in white matter abnormalities and other brain imaging markers. Follow-up will continue until the end of 2027 to track cognitive state and related outcomes. This observational study allows researchers to closely study CSVD progression and related factors over several years.

Cohort Study of Inpatients and Outpatient Patients With Cerebral Small Vessel Disease