Actively Recruiting
A Cohort Study of Risk Factors and Prognosis for Frequent Acute Asthma Exacerbations Phenotype
Led by Peking University Third Hospital · Updated on 2024-10-01
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating frequent acute exacerbations in asthma, which are sudden worsening episodes that significantly impact health and healthcare resources. This study aims to identify characteristics and risk factors of patients with frequent exacerbations compared to those with fewer episodes, regardless of asthma severity. It also seeks to develop a predictive model and understand the prognosis and treatment responses of this subgroup, which may represent a distinct asthma type. This observational study involves two groups: asthma patients with frequent exacerbations and those without. There is no intervention or treatment applied as part of this research. Instead, it focuses on collecting detailed information about clinical features, inflammation markers, lung function, comorbidities, environmental exposures, and imaging findings over time to better understand these patterns. Participants will attend outpatient visits where researchers will assess their asthma symptoms, perform lung function tests and lung CT scans, and collect blood and sputum samples to measure inflammation markers. These assessments are done at baseline and followed up for one year to track acute exacerbations and other health changes. The main outcome measured is the frequency of acute asthma exacerbations, with additional evaluations of immune markers and lung health to support the study goals.
CONDITIONS
Brief Title
A Cohort Study of Risk Factors and Prognosis for Frequent Acute Asthma Exacerbations Phenotype
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with asthma according to guidelines attending the outpatient clinic at Peking University Third Hospital
- Adults aged 18 to 80 years
- Both male and female patients
You will not qualify if you...
- Diagnosis of chronic obstructive pulmonary disease, bronchiectasis, pneumonia, or obstructive sleep apnea hypoventilation syndrome
- Presence of acute or chronic respiratory failure
- Severe cardiovascular disease
- Active malignancy (cancer)
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 year
Participants who undergo routine care are observed to assess risk factors and prognosis for frequent acute asthma exacerbations.
Baseline visit and periodic follow-up visits during 1 year
Trial Site Locations
Total: 1 location
1
Peking University third hospital
Beijing, Beijing Municipality, China, 100191
Actively Recruiting
Research Team
C
Chun Chang
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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