Actively Recruiting
Cohort of Twin Pregnancy and the Offspring
Led by Fudan University · Updated on 2025-03-14
1000
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Twin pregnancy carries increased risks for both mother and babies, including conditions such as high blood pressure during pregnancy, early labor, growth problems in the womb, and others. Researchers aim to better understand these risks by studying the molecular changes and identifying markers that could lead to new treatments. This study also uses twin pregnancies, especially those sharing a placenta, to explore differences in gene regulation before and after birth in twins with identical genetics. The study follows a group of women with twin pregnancies and their children from the time twins are diagnosed until the children reach three years old. Researchers collect various biological samples such as maternal blood, placental tissue, cord blood, urine, and stool at specific times. There is no treatment given, as this is an observational study focused on collecting data and samples. Participants will provide information about the pregnancy, as well as mental, physical, and social details about the children. The research team will measure outcomes such as the occurrence of maternal and fetal complications up to 42 days after birth. They will also analyze molecular profiles in the placenta immediately after delivery and assess child neurodevelopment at age three. The study is expected to last six years, including a 2.5-year recruitment period to gather participants.
CONDITIONS
Brief Title
Cohort of Twin Pregnancy and the Offspring
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Maternal age >18 years old.
- Twin pregnancy.
You will not qualify if you...
- Fetal chromosomal or congenital abnormalities.
- Stillbirth.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From confirmation of pregnancy to 42 days postpartum
Participants who undergo routine care are observed from confirmation of twin pregnancy through 42 days postpartum with collection of biological samples including maternal blood, placental tissues, cord blood, urine, and stool.
Multiple visits during pregnancy and up to 42 days postpartum
Duration - Up to 3 years after delivery
Participants and their offspring are monitored for maternal and offspring outcomes including neurodevelopment up to 3 years after delivery.
Visits at 3 years of age for offspring assessment
Trial Site Locations
Total: 1 location
1
Obstetrics and Gynecology Hospital of Fudan University
Shanghai, Shanghai Municipality, China, 200011
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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