Actively Recruiting
Cold Atmospheric Plasma for Moderate-to-severe Acne Vulgaris Study
Led by Shenyang Medical College · Updated on 2026-01-02
220
Participants Needed
1
Research Sites
73 weeks
Total Duration
On this page
Sponsors
S
Shenyang Medical College
Lead Sponsor
T
the 989th Hospital of Chinese People's Liberation Army Joint Logistic Support Force
Collaborating Sponsor
AI-Summary
What this Trial Is About
Acne vulgaris is a common, chronic inflammatory skin disease with complex pathogenesis and limited therapeutic options, especially for moderate-to-severe cases. Standard treatments-including topical and oral agents-are often constrained by side effects, antimicrobial resistance, and treatment resistance. Cold atmospheric plasma (CAP), a novel technology that generates reactive oxygen and nitrogen species, has demonstrated antimicrobial and tissue-regenerative properties in dermatology, but robust clinical evidence in acne management remains scarce. Existing data suggest promising efficacy and safety, yet its use in moderate-to-severe acne vulgaris has not been adequately investigated. This study aims to evaluate the efficacy and safety of two self-developed CAP devices as a potential innovative therapy for moderate-to-severe acne vulgaris.
CONDITIONS
Official Title
Cold Atmospheric Plasma for Moderate-to-severe Acne Vulgaris Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18-40 years
- Clinically diagnosed with moderate to severe acne vulgaris (Pillsbury grade III or IV, lesion count 6)
- Agree to use effective contraception during treatment
- Signed written informed consent form
You will not qualify if you...
- Pregnant or breastfeeding women
- Allergy to any active component of cold atmospheric plasma
- Use of systemic antibiotics within 4 weeks before enrollment
- Presence of dyslipidemia or other severe systemic diseases
- Participation in another clinical trial within the past 3 months or currently enrolled
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
the 989th Hospital of Chinese People's Liberation Army Joint Logistic Support Force
Luoyang, Henan, China
Actively Recruiting
Research Team
Y
Yun-En Liu, MD
CONTACT
L
Lin Tao, MM
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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