Actively Recruiting
Cold-induced Brown Fat Activation and Hepatic Steatosis
Led by Medical University of Vienna · Updated on 2024-03-13
26
Participants Needed
1
Research Sites
410 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In the recent years, research on brown adipose tissue (BAT) revealed that larger amounts as well as higher activity thereof are associated with a favourable metabolic phenotype. Longitudinal studies which applied recurrent cooling sessions demonstrated a high plasticity of BAT which significantly increased in size and activity during these studies. These changes were accompanied by improvements in body fat mass as well as insulin sensitivity. Non-alcoholic fatty liver disease (NAFLD) is estimated to advance to the primary cause of liver cirrhosis and hepatocellular carcinoma in the following years. Besides predisposing genetic and possibly nutritional factors, the insulin resistance syndrome and obesity are the main factors contributing to this excessive hepatic lipid accumulation. The aim of this study is to investigate whether BAT recruitment via cold-acclimation results in decreased hepatic lipid content in overweight/obese patients with NAFLD.
CONDITIONS
Official Title
Cold-induced Brown Fat Activation and Hepatic Steatosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Body mass index 28 - 40 kg/m²
- Hepatic lipid content greater than 10%
You will not qualify if you...
- Endocrine disease except treated hypo-/hyperthyroidism and certain hypertriglyceridemia (less than 500 mg/dl) and untreated type II diabetes mellitus with fasting glucose below 140 mg/dl
- Use of beta-blockers, alpha-blockers, and rilmenidine
- Chronic kidney disease
- Inflammatory bowel disease
- Active malignant disease
- Autoimmune disease
- Chronic alcohol abuse or alcohol consumption over 30g per day for men or 20g per day for women
- Transferrin saturation greater than 40%
- Serum alpha-1 antitrypsin below 90 mg/dl
- Serum ceruloplasmin below 20 mg/dl
- Positive serology for autoimmune hepatitis
- Positive hepatitis serology
- Liver cirrhosis
- Portal hypertension
- Pregnancy
- Contraindications for magnetic resonance imaging
AI-Screening
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Trial Site Locations
Total: 1 location
1
Medical University of Vienna
Vienna, Austria, 1090
Actively Recruiting
Research Team
F
Florian Kiefer, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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