Cold Snare Polypectomy for Duodenal Adenomas in Familial Adenomatous Polyposis

What this Trial Is About

Researchers are collecting prospective observational data on patients diagnosed with Familial Adenomatous Polyposis (FAP) who are undergoing cold snare polypectomy to remove duodenal adenomas. FAP is a genetic condition causing numerous colorectal polyps and has a high risk of colorectal cancer if untreated. Upper gastrointestinal adenomas are common in FAP, and managing duodenal adenomas remains challenging despite surgical advances. The study focuses on evaluating the cold snare polypectomy technique, which avoids thermal therapy by removing adenomas using a cold snare, potentially reducing bleeding risks seen with other methods like endoscopic mucosal resection (EMR). This method has been previously used safely for colorectal polyps and in small case series for duodenal adenomas but has not been studied extensively in larger groups. Patients with FAP and duodenal adenomas undergoing this procedure are observed over time. Participants are monitored for serious and non-serious adverse events over three years, including procedure duration, perforations, post-procedure pain, hospital readmissions, and changes in Spigelman stage—a system that classifies duodenal adenoma severity. The study tracks safety outcomes and the procedure's effects during routine surveillance for FAP, with no intervention beyond observation of standard care.

Cold Snare Polypectomy for Duodenal Adenomas in Familial Adenomatous Polyposis