Actively Recruiting
Cold Versus Room Temperature Storage of Platelets for Bleeding in Hematologic Malignancy - a Pilot Trial
Led by Ottawa Hospital Research Institute · Updated on 2025-07-31
50
Participants Needed
1
Research Sites
84 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a pilot trial to discover the feasibility of recruiting 50 pts over the course of 12 months. The trial is testing the efficacy of using cold-stored vs. room temperature stored (current standard of care) platelets to treat bleeding in persons with hematological disorders and thrombocytopenia.
CONDITIONS
Official Title
Cold Versus Room Temperature Storage of Platelets for Bleeding in Hematologic Malignancy - a Pilot Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 or older admitted to Malignant Hematology ward with hematologic malignancy or marrow aplasia, including those undergoing chemotherapy, immunotherapy, hematopoietic stem cell transplant, or admitted for symptom management
- Moderate thrombocytopenia with platelet count between 10 and 100 x 10⁹/L
- Platelet transfusion ordered to treat bleeding
You will not qualify if you...
- Severe thrombocytopenia with platelet count less than 10 x 10⁹/L
- Known platelet refractoriness requiring HLA or HPA selected platelet concentrates
- International normalized ratio (INR) greater than 2.0
- Activated partial thromboplastin time (aPTT) greater than 40 seconds
- Receiving therapeutic anticoagulation (unfractionated heparin, low molecular weight heparin, warfarin, direct oral anticoagulant)
- Known congenital bleeding disorder
- History of unprovoked venous thromboembolic disease
- Platelet transfusion for grade 2 or higher bleeding in the past 24 hours
- Order for multiple platelet transfusions at once
- Refusal of blood transfusion
- Prior participation in CoVeRTS-HM trial
- Participation in other clinical trials with interventions affecting CoVeRTS-HM treatment or outcomes
- Unable or unwilling to provide informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The Ottawa Hospital - General Campus
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
Research Team
J
Johnathan M Mack, MD
CONTACT
A
Alan Tinmouth, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
2
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