Comparing Two Reconstruction Methods After Colectomy in Adults With Ulcerative Colitis in Sweden and England

What this Trial Is About

Researchers are comparing two main surgical reconstruction options after colectomy for adult patients with ulcerative colitis ileal pouch anal anastomosis IPAA and ileorectal anastomosis IRA. This study aims to provide detailed information on patient satisfaction, quality of life, function, and complications between these two approaches, addressing a gap due to lack of prospective randomized trials. Patients are informed and choose their preferred surgery, with some followed as controls based on eligibility or choice to decline reconstruction. Participants who are eligible for both procedures choose either IPAA or IRA, while others may only qualify for one method or decline reconstruction and keep an ileostomy. The study includes multiple groups those selecting either surgery, those eligible for only one, and those who decline reconstruction. The surgeries involve either connecting the ileum to the rectum IRA or creating a pouch from the ileum connected to the anus IPAA. Patients are followed over time to assess outcomes. During the study, patient satisfaction is measured at 2 months, 1 year, and 5 years after surgery. Additional assessments include quality of life surveys, sexual function indexes for females and males, health scales, and scores related to bowel function. Researchers also monitor complications such as failure and reoperations at multiple time points. The study spans long-term follow-up to evaluate the impact of each reconstructive method on patient well-being and function.

Colectomy Reconstruction for Ulcerative Colitis, Ileorectal Anastomosis vs Ileal Pouch-Anal Anastomosis in Ulcerative Colitis.