Actively Recruiting
Colistin Dosage Prsonalization Approach
Led by Mahmoud I Mostafa · Updated on 2025-08-13
100
Participants Needed
1
Research Sites
65 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A few studies have evaluated higher doses or the administration or a loading dose, which is routine in adults, in pediatric patients, and reported improved colistin exposure without an increased risk of nephrotoxicity The main questions it aims to answer are What is the optimal dosing strategies of intravenous colistin for the treatment of multidrug-resistant gram-negative bacterial infections in preterm neonates? What is the incidence of AKI? What is the factors increasing AKI incidence? A single center retrospective and comparative study, cohort study compare low dose 5 mg/kg/day versus 7.5mg/kg/day
CONDITIONS
Official Title
Colistin Dosage Prsonalization Approach
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Neonates aged between 0 and 30 days born before 37 weeks
- Critically ill patients with nosocomial infection with proven culture-resistant gram-negative bacteria
- Neonates who are indicated for colistin and started colistin therapy for at least 48 hours
You will not qualify if you...
- Serum creatinine ≥1.5 baseline before colistin treatment
- Received colistin before neonatal intensive care unit stay
- Administration of concurrent nephrotoxic drugs including amphotericin, gentamicin, or amikacin
- Presence of major congenital anomalies or previous renal impairment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cairo univrsity Hospitals
Cairo, Egypt, 11435
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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