Actively Recruiting
Advancing Safe, Comprehensive, Digitally-Enabled Cancer Pain Management (ASCENT)
Led by Mayo Clinic · Updated on 2026-04-13
660
Participants Needed
3
Research Sites
30 weeks
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating a collaborative pain management program called ASCENT designed to improve cancer pain care in cancer survivors. Cancer pain remains a significant source of suffering and disability, often undertreated or resulting in inappropriate opioid use. This study aims to assess how a personalized, digitally facilitated intervention involving educational materials and support from community health workers and pain care managers can improve pain control and reduce opioid dependency risks. Participants are randomly assigned to one of two groups. The first group receives enhanced usual care, including access to the ASCENT educational guide on pain self-management. The second group receives the same guide plus three video or phone coaching sessions with community health workers and pain care managers to develop and follow a personalized pain management plan. Follow-up calls occur every two weeks to monitor progress and address pain-related issues. During the study, participants will complete assessments at baseline, 3 months, and 6 months, measuring pain levels, physical function, quality of life, mood, sleep, employment status, and opioid use. Researchers will also monitor adherence to the pain care plan and healthcare usage. The study is fully remote, with no travel required, and aims to gather data on how collaborative, multimodal pain care affects cancer survivors over a 6-month period.
CONDITIONS
Brief Title
A Collaborative Intervention for Improving Cancer Pain Management in Cancer Survivors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- A diagnosis of liquid or solid cancer with visits at a participating Mayo Clinic site in the past 15 years, including lymphoma, myeloma, and chronic leukemias
- Age 18 years or older
- Numeric Rating Scale pain score of 5 or higher
- Pain that developed or worsened after cancer diagnosis
- Identify as rural, Hispanic, or both
You will not qualify if you...
- Patient Health Questionnaire-8 score of 13 or higher
- Enrollment in hospice care
- Living in skilled nursing, inpatient rehabilitation, or long-term care facilities
- Recent or upcoming visits with Palliative Care or Pain Clinic within two months
- Any mention of hospice referral in oncology notes
- Confined to a bed or chair for more than one-third of waking hours
- Currently homeless or feeling unsafe at home
- New or worsening chest pain or pressure
- Back pain with new or worsening weakness, bowel/bladder control issues, or walking difficulty
- New or worsening headaches with vision changes, nausea, balance, or speech problems
- Positive screen for monthly or more frequent non-cannabis drug use
- Unable to participate due to medical or psychological reasons
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (remote)
Duration - Up to 6 months
Participants receive either enhanced usual care with access to educational and pain self-management materials, or the ASCENT guide plus attend three video or phone calls with their community health worker and/or pain care manager to develop and discuss a personalized pain management plan.
3 video or phone calls plus biweekly follow-up contacts
Duration - Up to 6 months
Participants are contacted every other week to monitor their progress and may receive additional contacts as needed based on their reported pain, symptoms, or barriers.
Biweekly remote contacts after initial calls
Trial Site Locations
Total: 3 locations
1
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259
Actively Recruiting
2
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224-9980
Actively Recruiting
3
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
J
Josiah Lulf
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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