Actively Recruiting
Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients
Led by Mayo Clinic · Updated on 2026-05-01
750
Participants Needed
9
Research Sites
261 weeks
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
E
Exact Sciences Corporation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study collects blood and stool samples from patients with suspected or diagnosed Lynch syndrome to evaluate a deoxyribonucleic acid (DNA) screening technique for the detection of colorectal cancer in Lynch syndrome patients.
CONDITIONS
Official Title
Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients at least 18 years of age
- Diagnosed with Lynch syndrome (mutation in MLH1, MSH2, MSH6, PMS2, EPCAM) or colorectal cancer with suspected Lynch syndrome
- Individuals diagnosed with early onset colorectal cancer (under 55 years old)
- Scheduled for colonoscopy or flexible sigmoidoscopy within 90 days before or after sample collection
- Agreed to participate and signed the study consent form
You will not qualify if you...
- Known cancer (stage I-IV) within 5 years prior to sample collection (excluding basal cell or squamous cell skin cancers)
- Received chemotherapy drugs for cancer treatment in the 5 years prior to sample collection
- Had any abdominal radiation therapy before sample collection
- Prior therapy to target lesion intended to completely remove or reduce the lesion before sample collection
- Prior diagnosis of non-Lynch hereditary colon cancer syndromes (such as familial adenomatous polyposis, MUTYH-associated polyposis, Peutz-Jeghers syndrome, juvenile polyposis syndrome, PTEN, POL)
- Bowel preparation less than 7 days before stool collection
- Oral or rectal contrast given within 7 days before stool collection
- Presence of ileostomy
- Use of enteral feeds or total parenteral nutrition
- Diagnosis of inflammatory bowel disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259
Actively Recruiting
2
University of California San Francisco
San Francisco, California, United States, 94115
Actively Recruiting
3
University of Colorado Anschutz Medical Center
Aurora, Colorado, United States, 80045
Actively Recruiting
4
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224
Actively Recruiting
5
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Not Yet Recruiting
6
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
7
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
8
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
9
University of Washington
Seattle, Washington, United States, 98102
Actively Recruiting
Research Team
R
Rosalie Himle
CONTACT
C
Clinical Trials Referral Office
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here