Actively Recruiting
Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
Led by Weill Medical College of Cornell University · Updated on 2025-11-14
2000
Participants Needed
1
Research Sites
848 weeks
Total Duration
On this page
Sponsors
W
Weill Medical College of Cornell University
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to obtain biologic materials from the blood, airways and/or urine of normal individuals and individuals with lung disease. The normal are used to establish a set of normal ranges for various parameters. These provide control information when compared to individuals with various pulmonary diseases, and will help in understanding of the etiology and pathogenesis of various lung diseases. The underlying hypothesis is that the pathologic morphological changes in the airway epithelium must be preceded by changes in the gene expression pattern of the airway epithelium and potentially in macrophages.
CONDITIONS
Official Title
Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to provide informed consent
- Male or female aged 18 years or older
- For healthy volunteers: no lung disease and inclusive of all races, ethnicities, HIV status, smoking status, and birth status
- For lung disease volunteers: diagnosed lung disease by symptoms, chest X-rays, pulmonary function tests, biopsy, family history, or related organ diseases
- Must provide HIV informed consent
- For cystic fibrosis subjects: homozygous for the 94F508 mutation with mild to moderate lung disease defined by FEV1 65%
- Clinical patients from WCMC/NYPH or PCNY with proven lung disease including blood eosinophil levels 65% for WCMC/NYPH patients
You will not qualify if you...
- Not in good overall health as determined by investigator during screening or before bronchoscopy
- History of chronic lung disease including asthma or recent acute pulmonary disease within 3 months for healthy volunteers
- Allergies to atropine, pilocarpine, isoproterenol, terbutaline, aminophylline, lidocaine, versed, valium, or any local anesthetic
- Pregnant or nursing females
- Unable to complete bronchoscopy due to health concerns
- For cystic fibrosis subjects: recent pulmonary exacerbation within 8 weeks
- Patients who refuse consent for clinical patient groups
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Weill Cornell Medical College and Weill Cornell Medical Center, Department of Genetic Medicine
New York, New York, United States, 10065-4870
Actively Recruiting
Research Team
N
Niamh Savage
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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