Research Study Collecting Blood, Airway, and Urine Samples from Adults With and Without Lung Disease to Study Lung Health and Disease

What this Trial Is About

Researchers are collecting blood, urine, and airway samples from both healthy individuals and those with lung diseases to study genetic expression and other biological factors. The goal is to establish normal ranges for various parameters and compare them with those affected by lung conditions like COPD, IPF, and interstitial lung diseases. This study helps improve understanding of the causes and development of lung diseases by examining changes in airway cells and macrophages before visible disease changes occur. Participants include healthy volunteers and those diagnosed with lung diseases. Samples collected may include blood, urine, nasal and airway brushings, biopsies, or washings. Bronchoscopy is used to gather airway cells in some participants. Clinical patients at certain centers may only provide nasal samples and a small blood sample. All sample collection occurs during separate study visits after informed consent. During the study, participants will provide biological samples and may be followed up with a phone call seven days after their visit. Researchers will analyze genetic material, proteins, and other markers to learn about lung disease causes and progression. The study focuses on comparing data from healthy individuals and lung disease patients, with no additional procedures for some clinical patients. Participation duration varies by visit schedule, and safety is monitored throughout.

Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies