Actively Recruiting
Collection of Blood, Bone Marrow, Skin, Saliva, and Stool Samples From Healthy Volunteers Used for Comparative Analysis of Myeloid Malignancies
Led by National Cancer Institute (NCI) · Updated on 2026-05-08
1000
Participants Needed
1
Research Sites
1559 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Myelodysplastic syndromes (MDS) are disorders of blood stem cells that can develop into blood cancers. Treatment options are limited. To find better treatments, researchers need to better understand how MDS develops. To do that, they must be able to compare biospecimens from people with the disease to those of healthy people. Objective: This study will create a database of biospecimens collected from healthy volunteers. Eligibility: Healthy people aged 18 and older. Design: Participants will be screened. They will have a physical exam with blood and urine tests. Up to 5 types of samples will be collected on 1 or more days within 1 month of screening: Blood: Blood will be drawn by inserting a needle into a vein. Saliva: Participants will scrape the insides of their cheeks with a brush. Stool: Participants will be given a container to collect stool at home. They will use a prepaid envelope to mail in the sample. Bone marrow: A sample of the soft tissue inside the bones will be drawn out. The area to be biopsied, usually the lower back, will be numbed. A needle will be inserted through a small cut to remove the sample. Participants' pain will be monitored; additional numbing medicine may be used. Skin: A piece of skin about 1/6 of an inch across will be cut away. Stitches may be used to close the wound. Participants will return to the clinic to have the stitches removed. Participants do not have to provide all of the samples listed. They will give each sample only once.
CONDITIONS
Official Title
Collection of Blood, Bone Marrow, Skin, Saliva, and Stool Samples From Healthy Volunteers Used for Comparative Analysis of Myeloid Malignancies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Healthy volunteers confirmed by medical history and physical exam within 3 months before study
- Complete blood count (CBC) within normal range per clinical standards
- Ability to understand and willing to sign consent form
You will not qualify if you...
- Active illnesses, immunodeficiency, history of opportunistic infection, autoimmune disease
- History or active cancer, except for non-melanoma skin cancer or carcinoma in situ of cervix or breast
- Prior organ, bone marrow, or peripheral blood stem cell transplant
- Antibiotic treatment within 3 months before study
- Current immunosuppressive medication use
- Symptoms like frequent diarrhea, constipation, bloating, or abdominal pain at least once a week in past 3 months
- History of HIV, hepatitis B, or hepatitis C infection
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
A
Ashley E Carpenter
CONTACT
K
Kathy L McGraw, Ph.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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