Genetic Study of Blood Samples in Men With Prostate Cancer at the National Cancer Institute

What this Trial Is About

Researchers are studying men with prostate cancer to better understand why some cases become resistant to hormone therapy, known as androgen-independent prostate cancer. The study focuses on genetic differences that may influence how aggressive the cancer becomes and its progression. This observational study collects genetic information to explore links between gene variations and prostate cancer outcomes. Participants diagnosed with prostate cancer will have blood samples collected at the National Cancer Institutes Medical Oncology Clinic. These samples will be used to extract DNA and white blood cells for genetic testing and creation of cell lines. Some participants may provide additional blood samples if needed. The study may also collect cell-free DNA and RNA from blood at multiple times to support future research, but healthy controls are not part of this comparison. During the study, participants provide blood samples mainly at their initial or follow-up clinic visits after consenting. Researchers will analyze these genetic materials to correlate gene variations with cancer prognosis and tumor characteristics. The study primarily measures the genetic material collected over time from participants. There is no treatment given, and participants continue their usual care outside the study.

Collection of Blood From Patients With Prostate Cancer