Bilateral orchiectomy with or without flutamide for metastatic prostate cancer.
M A Eisenberger, B A Blumenstein, E D Crawford...
https://pubmed.ncbi.nlm.nih.gov/9761805Actively Recruiting
Age: 18Years +
MALE
ID00923221
Collection of Blood From Patients With Prostate Cancer
Led by National Cancer Institute (NCI) · Updated on 2026-06-08
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying prostate cancer in men to understand why some cases stop responding to anti-androgen treatments, focusing on genetic differences. This observational study aims to collect blood samples from men diagnosed with prostate cancer to analyze gene variations that might influence disease progression and prognosis. Participants with prostate cancer visiting the NCI Medical Oncology Clinic will provide blood samples, generally once, for DNA extraction and genetic analysis. Additional samples may be collected if needed. These samples will be used to study genetic material, including cell-free DNA and RNA, at multiple timepoints to explore links with cancer outcomes. No comparisons will be made with healthy individuals. During the study, participants will have blood drawn after consenting, with samples used for genotyping and creating cell lines. Researchers will correlate genetic differences with disease prognosis indicators such as tumor grade and survival time. The study involves ongoing sample collection and genetic analysis, with no direct interventions or treatments administered.
CONDITIONS
Brief Title
Collection of Blood From Patients With Prostate Cancer
Who Can Participate
Age: 18Years +
MALE
Eligibility Criteria
You may qualify if you...
- Individuals 18 years of age and older are eligible.
- Individuals with a diagnosis of prostate cancer are eligible.
You will not qualify if you...
- Children are not eligible.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Sample Collection
Duration - Varies per participant
Participants provide blood samples for genomic DNA extraction and establishment of individual cell lines. Additional samples may be collected if needed. Blood samples for cell-free DNA and RNA may be collected at multiple timepoints for future investigations.
1 or more visits depending on sample requirements
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
P
Paula A Carter, R.N.
W
William D Figg, Pharm.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
A reevaluation of nonhormonal cytotoxic chemotherapy in the treatment of prostatic carcinoma.
M A Eisenberger, R Simon, P J O'Dwyer...
https://pubmed.ncbi.nlm.nih.gov/2409240Molecular genetics and epidemiology of prostate carcinoma.
E Ruijter, C van de Kaa, G Miller...
https://pubmed.ncbi.nlm.nih.gov/10047972