Actively Recruiting
Collection of Clinical Data and Specimens for Research in Hearing, Balance, Taste, Smell, Voice, Speech, and Language Disorders.
Led by National Institute on Deafness and Other Communication Disorders (NIDCD) · Updated on 2026-04-28
600
Participants Needed
1
Research Sites
508 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: People with hearing, balance, and taste, smell, voice, speech, language, and other Ear, Nose, and Throat (ENT) disorders may seek treatment at the National Institute on Deafness and Other Communication Disorders (NIDCD). Some of these people may benefit from enrolling in the NIDCD intramural research program to receive their care. Enrolling will also allow investigators to collect participants clinical data and specimens for future research. Objective: This natural history study has 2 goals: (1) to collect data and specimens that may be used for research; and (2) to evaluate participants who may be candidates for other research studies. Eligibility: People aged 2 years or older with a hearing, balance, and communication disorder. Those at risk or who are suspected of having such a disorder are also eligible. Design: Participants will be screened. Their medical records will be reviewed. Participants will agree to have their medical data used for research. Specimens such as blood or other tissue samples may also be used for research. All data and specimens will be collected during their routine care visits. All tests done will be the normal care for each participant s condition. No tests will be done solely for research. Some of these tests may require blood or tissue samples. Some may use special tools to test hearing and balance. Some may test heart or lung function. These tests may also include different types of imaging scans. All tests will be explained. Participants may ask questions at any time. Participants may remain in this study for up to 2 years. If they need further care, they may sign a new consent. ...
CONDITIONS
Official Title
Collection of Clinical Data and Specimens for Research in Hearing, Balance, Taste, Smell, Voice, Speech, and Language Disorders.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must be age 2 years or older if procedures or treatment are required.
- Patients at risk, suspected of having, have a history of, or currently have a diagnosed hearing, balance, taste, smell, voice, speech, language, and other ENT disorder.
- An NIDCD clinical investigator and principal investigator determine it is in the interest of the patient and NIDCD Clinical Research Program for the patient to undergo consult, treatment, or follow-up at NIDCD/NIH.
- Patient or legally authorized representative is able to provide informed consent. Consent for patients under 18 years old must be signed by a parent or guardian.
- A subset of participants with known or suspected PIEZO2-related sensory dysfunction may be asked to participate in optional remote taste and oral somatosensory testing.
You will not qualify if you...
- Candidates who do not meet the inclusion criteria.
- Candidates with medical or unstable conditions for which NIDCD and Clinical Center consultative services cannot provide or support optimal care.
- Participants without known or suspected PIEZO2-related sensory dysfunction will not be asked to complete the sensory testing component.
- For taste testing only, exclusion includes active oral sores, open cuts, or significant oral pain.
- Recent oral surgery or dental procedures within the past 7 days.
- Known allergy or hypersensitivity to tannins or polyphenols.
- Acute upper respiratory infection or conditions that may interfere with taste perception.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
M
Marcia L Mulquin, R.N.
CONTACT
J
Joshua M Levy, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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