Concurrent sickle-cell anemia and alpha-thalassemia: effect on severity of anemia.
S H Embury, A M Dozy, J Miller...
https://pubmed.ncbi.nlm.nih.gov/6172710Actively Recruiting
Age: 18Years - 70Years
All Genders
Healthy Volunteers
ID03937817
Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-06-05
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how variations in alpha and beta globin affect blood disorders like malaria, sickle cell disease, and other related conditions involving inflammation or blood vessel problems. This observational study collects biological samples from both healthy volunteers and people with blood disorders to support basic and clinical research. The goal is to improve understanding of how these globin variants influence disease and normal physiology. Participants may provide one or more types of samples over a period of up to five years. Samples collected include saliva, urine, blood and blood waste products, fat tissue from a small biopsy, and lung cells or mucus collected via bronchoscopy. Some procedures involve sedation and additional tests such as physical exams, chest x-rays, and heart monitoring. Participants can choose which samples to give and may decline any. During the study, participants undergo screening including medical history, physical exams, and blood and urine tests. Researchers will collect and store samples for genetic testing and other analyses throughout the study period. The primary outcome is the collection of these various biological specimens for ongoing research. Participation may last several years, with continuous opportunities to provide samples and be monitored as needed.
CONDITIONS
Brief Title
Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants
Who Can Participate
Age: 18Years - 70Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Aged 18-70 years
- Able to provide informed consent
- Willing to allow biological samples to be stored for future research
- Willing to provide one or more of the following samples: saliva, urine, blood, blood waste products, adipose tissue, bronchial brushing, and/or bronchoalveolar lavage samples
- Willing to allow genetic testing on collected biological samples
You will not qualify if you...
- Pregnant
- Positive test for hepatitis B virus, hepatitis C virus, or HIV
- Any condition requiring active medical intervention or monitoring to avoid serious health risk
- Any condition that the principal investigator deems unsafe for participation
- For blood donation: hemoglobin less than 10 g/dL for healthy females, less than 12 g/dL for healthy males, or less than 6 g/dL for those with sickle cell disease or chronic anemia
- For adipose tissue biopsy: currently taking anticoagulants, platelet count below 100,000/microL, history of keloid formation, adverse reaction to local anesthetics, or any condition contraindicating the procedure
- For bronchoscopy: abnormal blood clotting times, platelet count below 150,000/microL, current use of anticoagulants, recent aspirin or NSAID use, pulmonary disorders, recent respiratory infection, adverse reactions to anesthetics, recent smoking, history of opioid use, drug or alcohol abuse, low lung function, active bronchospasm, lidocaine allergy, or any condition contraindicating the procedure
- Co-enrollment allowed with PI notification
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Sample Collection
Duration - Throughout study
Participants provide biological specimens such as saliva, urine, blood, blood waste products, adipose tissue, bronchial brushing, and/or bronchoalveolar lavage samples for research purposes.
1 to multiple visits depending on sample type and participant availability
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
M
Mary J Jackson, R.N.
H
Hans C Ackerman, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
The α-thalassemias.
Frédéric B Piel, David J Weatherall
https://pubmed.ncbi.nlm.nih.gov/25390741Endothelial cell expression of haemoglobin α regulates nitric oxide signalling.
Adam C Straub, Alexander W Lohman, Marie Billaud...
https://pubmed.ncbi.nlm.nih.gov/23123858