Study to Collect Biological Samples From Adults With Blood Disorders and Healthy Volunteers for Research on Globin Variants and Related Diseases

What this Trial Is About

Researchers are studying blood disorders such as sickle cell disease and malaria to better understand how alpha and beta globin variants affect these conditions and other diseases involving inflammation or vascular problems. This research involves collecting biological samples from both people with blood disorders and healthy volunteers to support laboratory and clinical studies. The goal is to learn more about the role of globin variants in normal human physiology and disease development. Participants will provide various biological samples over a period of up to 5 years. Samples may include saliva, urine, blood, blood waste products, fat tissue, and lung mucus and cells obtained via bronchoscopy. Some procedures involve sedation and minor tissue collection, while others involve simple collection methods like spitting or urinating into a cup. Participants can choose which samples to provide and are not required to give all types. Throughout the study, participants will undergo initial screening with medical history, physical exams, blood and urine tests, and may have chest x-rays and heart tests if undergoing bronchoscopy. Researchers will collect and store the biological samples for ongoing research. The study will monitor safety and participant health over several years, gathering information to advance understanding of blood disorders and related conditions.

Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants