Actively Recruiting
Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-05-01
300
Participants Needed
1
Research Sites
496 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Blood disorders like sickle cell disease and malaria affect many people around the world. Researchers want to learn more about blood disorders. To do this, they need to collect biological samples from people with blood disorders. They also need to collect samples from healthy people. Objective: To collect samples to use for research on blood disorders. Eligibility: People ages 18-70 who have blood disorders. Healthy volunteers without blood disorders are also needed. Design: Participants will be screened with a medical history, physical exam, and blood and urine tests. Participants will give one or more samples. They will give them over 5 years. They can choose not to give any of the samples: Saliva: Participants will spit into a tube. They may also have the inside of their mouth swabbed. Urine: Participants will urinate into a cup. Blood and blood waste products: Blood will be taken through a needle in the participant s arm. Fat samples: An area on the participant s belly or buttock will be numbed. A small cut will be made into the skin and a small piece of fat removed. Mucus and cells from the lungs: The participant will be sedated. A flexible tube will be inserted through the nose or mouth into the lung airways. These participants will also have a physical exam, chest x-ray, and heart tests after the procedure.
CONDITIONS
Official Title
Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18-70 years
- Able to give informed consent
- Willing to allow storage of biological samples for future research
- Willing to provide one or more of the following samples: saliva, urine, blood, blood waste products, fat tissue, bronchial brushing, and/or bronchoalveolar lavage
- Willing to allow genetic testing on collected samples
You will not qualify if you...
- Currently pregnant
- Positive test results for hepatitis B, hepatitis C, or HIV
- Any condition requiring active medical treatment or monitoring to prevent serious health risks
- Any condition the principal investigator believes makes participation unsafe
- For blood donation: hemoglobin below 10 g/dL for healthy females, below 12 g/dL for healthy males, or below 6 g/dL for those with sickle cell disease or chronic anemia
- For fat biopsy: taking blood thinners, low platelet count below 100,000/microL, history of keloid scars, allergy to local anesthetics, or any other contraindication
- For bronchoscopy: abnormal blood clotting tests, low platelets below 150,000/microL, taking blood thinners, recent aspirin or NSAID use, lung diseases, recent respiratory infection, allergies to anesthetics, recent smoking, opioid use, drug or alcohol abuse, poor lung function, active bronchospasm, lidocaine allergy, or other contraindications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
M
Mary J Jackson, R.N.
CONTACT
H
Hans C Ackerman, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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