Study of Lung and Nasal Fluid and Tissue Samples to Understand Respiratory Infection Risks in Healthy Volunteers and Patients

What this Trial Is About

Researchers are studying differences in lung and nasal fluid and tissue samples between healthy people and those with a history of lung infections to understand susceptibility to respiratory infections. This observational research involves both adults and children enrolled in National Institutes of Health NIH protocols, aiming to analyze immune function and inflammatory responses in these groups. The study will collect various specimens and bedside measurements to explore new pathways related to infectious diseases. Participants may undergo procedures such as bronchoscopy with bronchoalveolar lavage, bronchial brushings, endobronchial biopsies, nasal mucosal scrape biopsies, sputum induction, and collection of exhaled breath condensate. Additional measurements include nasal nitric oxide production, nasal potential difference, exhaled aerosol mask sampling, cough aerosol collection, exhaled particle collection, and Lung Clearance Index LCI testing. These samples and data will be stored or transferred to laboratories for detailed investigation. Participants will have medical history reviews, physical exams, blood and urine tests, ECGs, and chest X-rays as part of assessments. Some may undergo treadmill stress tests if over 45 with chest symptoms. Specimens collected through various methods will help researchers compare immune responses. The trial includes healthy volunteers and patients with infection susceptibility, with procedures designed to monitor safety and collect detailed respiratory data over time.

Collection of Lung Fluid and Tissue Samples for Research