Investigative bronchoprovocation and bronchoscopy in airway diseases.
William W Busse, Adam Wanner, Kenneth Adams...
https://pubmed.ncbi.nlm.nih.gov/16020805Actively Recruiting
Age: 5Years - 100Years
All Genders
Healthy Volunteers
ID00471250
Research Respiratory Tract Procedures for Lung Fluid and Tissue Sample Collection and Analysis in Healthy and Infected Individuals
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2026-06-01
550
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are examining fluid and tissue samples from the lungs and noses of healthy individuals and people with a history of lung infections to identify differences that may relate to susceptibility to certain infections. This observational study includes healthy volunteers and patients aged 5 to 75 years who are followed at the National Institutes of Health (NIH). The goal is to better understand immune function and pathways involved in respiratory infections by comparing samples from these groups. Participants may undergo various procedures including bronchoscopy with bronchoalveolar lavage, bronchial brushings, and endobronchial biopsies in adults; nasal mucosal biopsies and brushings; sputum induction; measurement of nasal nitric oxide and nasal potential difference; collection of exhaled breath condensate, aerosol samples, and cough aerosols; and Lung Clearance Index testing. These samples will be analyzed for cellular and acellular components in specialized laboratories. During the study, participants will have medical history reviews, physical exams, blood and urine tests, chest X-rays, electrocardiograms, and treadmill stress tests if indicated. Bronchoscopy procedures involve sedation and numbing for comfort while collecting samples from the airways. Researchers will measure immune function differences and monitor various respiratory and physiological parameters over time. Participants will also provide informed consent and arrange for transportation home after procedures, with the total participation involving multiple sample collections and assessments.
CONDITIONS
Brief Title
Collection of Lung Fluid and Tissue Samples for Research
Who Can Participate
Age: 5Years - 100Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Age between 5 and 75 years inclusive
- Enrolled regardless of gender, race, or ethnicity
- Able to provide proof of identity
- Able and willing to complete informed consent
- Able and willing to arrange transportation after procedures
- Willing to donate blood and respiratory samples for research
- Good general health without significant medical history
- Stable vital signs (for nasal procedures and sputum induction)
- Must be enrolled in a concurrent NIH protocol and under care of a primary physician outside NIH (patients)
- For healthy volunteers, NIH staff are eligible
You will not qualify if you...
- Younger than 5 years or older than 75 years
- Current smoker, smoking history of 10 pack-years or more, or tobacco-free less than one year (healthy volunteers)
- Positive HIV status
- Acute or chronic hepatitis
- Pregnancy or breastfeeding
- Active medical problems including bleeding disorders, asthma, pulmonary disorders, or unstable heart conditions
- History of allergic reaction to lidocaine or sedative/narcotic medications
- Use of immunosuppressive, cytotoxic, corticosteroid inhalers, or long-acting beta-agonists in past 3 months
- Use of platelet inhibitors (aspirin, NSAIDs) within 7 days or clopidogrel within 14 days before procedures
- Significant uncontrolled hay fever or recent upper respiratory infections (nasal procedures)
- History of turbinectomy or significant nasal pathology (nasal procedures)
- Any medical, psychiatric, social, or occupational condition impairing informed consent or participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Single day or multiple days depending on procedures performed
Participants undergo one or more respiratory tract procedures to collect lung fluid and tissue samples for research, including bronchoscopy with bronchoalveolar lavage, sputum induction, nasal mucosal biopsies, exhaled breath condensate collection, and other airway assessments.
1 to multiple visits depending on procedures selected
Long-term Monitoring
Duration - Up to 10 years
Participants are observed over an extended period to analyze immune function and investigate susceptibility to respiratory infections based on collected samples and measurements.
Periodic visits may occur for follow-up assessments
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
C
Chevalia J Robinson, R.N.
A
Andrew J Lipton, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Clinical role of bronchoalveolar lavage in adults with pulmonary disease.
R A Goldstein, P K Rohatgi, E H Bergofsky...
https://pubmed.ncbi.nlm.nih.gov/2200319Brush biopsy and mucosal biopsy.
A Bush, P Pohunek
https://pubmed.ncbi.nlm.nih.gov/10934126