Actively Recruiting
Collection of Lung Fluid and Tissue Samples for Research
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2026-05-07
550
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will collect fluid and tissue specimens from the lungs and nose of healthy people and people with a history of lung infections. The specimens will be examined for differences between the two groups that may be associated with susceptibility to certain infections. Healthy normal volunteers and people with a history of lung infections between 18 and 75 years of age who are followed at NIH may be eligible for this study. Participants undergo the following procedures: Medical history and physical examination. Blood and urine tests. Electrocardiogram (ECG) and chest x-ray. Treadmill exercise stress test (for people over 45 years old with a history of chest pain or ECG abnormalities). Bronchoscopy: The subject s nose and throat are numbed with lidocaine and a sedative is given for comfort. A thin flexible tube called a bronchoscope is advanced through the nose or mouth into the lung airways to examine the airways carefully. Fluid collection during the bronchoscopy using one of the following methods: * Bronchoalveolar lavage: Salt water is injected through the bronchoscope into the lung and immediately suctioned out, washing off cells lining the airways. * Bronchial brushings: A brush-tipped wire enclosed in a sheath is passed through the bronchoscope and a small area of the airway tissue is gently brushed. The brush is withdrawn with some tissue adhering to it. * Endobronchial biopsies: Small pinchers on a wire are passed through the bronchoscope and about 1 to 2 millimeters of tissue is removed. * Nasal scrape: A small device is used to scrape along the inside of the nose to collect some cells. * Sputum induction * Exhaled breath condensate to obtain specimens for in vitro investigations and comparisons of both the cellular and acellular components. * Nasal nitric oxide production * Nasal potential difference * Exhaled aerosol mask sample collection * Cough aerosol collection * Exhaled particle collection * Lung Clearance Index (LCI)
CONDITIONS
Official Title
Collection of Lung Fluid and Tissue Samples for Research
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy volunteers aged 18 to 75 years for bronchoscopy procedures
- NIH staff eligible
- Ability to provide proof of identity
- Willingness to complete informed consent
- Ability to arrange transportation after procedures
- Willingness to donate blood and respiratory samples for future research
- Good general health with no significant medical history or abnormal physical exam
- Normal screening lab tests including blood counts, chemistry, HIV and hepatitis tests, coagulation, urinalysis
- Negative urine pregnancy test for females within 1 week of participation and use of birth control
- Chest x-ray or chest CT within 7 days if not previously done
- Stable vital signs for nasal mucosal biopsy and related procedures
- Participants aged 5 years and older for nasal mucosal biopsy, nasal nitric oxide measurement, nasal potential difference, sputum induction, aerosol sampling, and Lung Clearance Index
- Patients aged 18 to 75 years with known or suspected respiratory infections enrolled in concurrent NIH protocols under external primary care
- Ability and willingness to complete informed consent and donate samples
You will not qualify if you...
- Age under 5 years for nasal mucosal and related procedures, under 18 or over 75 for bronchoscopy procedures
- Smoking history of 10 pack-years or more, current smokers, or tobacco-free less than 1 year
- Positive HIV status without appropriate negative PCR confirmation
- Acute or chronic hepatitis
- Pregnancy or breastfeeding
- Active medical problems including bleeding disorders, pulmonary diseases such as asthma, COPD, pulmonary fibrosis, pulmonary hypertension, or requirement of supplemental oxygen
- History of allergic reactions to lidocaine, sedatives, or narcotics used in procedures
- Use of immunosuppressive or cytotoxic medications, inhaled corticosteroids or long-acting beta-agonists within 3 months
- Use of platelet inhibitors including aspirin or NSAIDs within 7 days or clopidogrel within 14 days before procedures
- Unstable angina, uncontrolled heart failure, or rhythm disturbances
- Significant kidney or liver disease
- Significant anemia with hemoglobin less than 7.5 grams/dl
- History of turbinectomy or significant nasal pathology preventing sample collection
- History of frequent colds, uncontrolled hay fever, recent or active upper respiratory infection
- Any condition impairing ability to give informed consent or contraindicating participation as judged by investigators
- History of asthma or reactive airway disease for sputum induction and related procedures
- Social, psychiatric, occupational, or other reasons that impair participation or consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
C
Chevalia J Robinson, R.N.
CONTACT
A
Andrew J Lipton, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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