Study of Stool Samples From Healthy Adults to Understand How Dairy Phages and Antibiotics Affect Gut Microbiome Balance

What this Trial Is About

Researchers are exploring how the community of microorganisms in the gut, including bacteria and viruses called phages, affect health by defending against pathogens, regulating the immune system, and aiding digestion. This study focuses on how phages found in dairy foods might help restore gut balance and diversity, especially after disturbances caused by antibiotics or extreme diets that disrupt the microbiota. The study involves collecting stool samples from healthy adult volunteers aged 18 to 60 who follow a varied and balanced omnivorous diet. It aims to model how dairy-derived phages influence the gut microbiomes recovery following antibiotic-related changes. The research will evaluate the role of these phages in promoting the restoration of intestinal homeostasis and overall microbial diversity. Participants will provide stool samples for analysis, and researchers will monitor gut microbiome shifts over up to three years to assess the impact of phages from dairy products. The study measures primary and secondary outcomes related to microbiome changes during this period. No treatments or interventions are administered, as this is an observational study involving healthy volunteers without specific diseases.

Collection of Stool From Healthy Donors for the ex Vivo Study of Shifts of Microbiome Induced by Dairy Phages and Antibiotics: a Model of Bacteria/Host Interaction (DAIRY-SHAPE)