Actively Recruiting

Age: 2Years - 100Years
All Genders
Healthy Volunteers
ID00071045

Collection of Blood, Bone Marrow, Urine, and/or Tissue Samples From Patients With Solid Tumors, Hematological Malignancies or Non-Malignant Hematologic Disorders or HLA Compatible Family Members

Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2026-06-05

6000

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying patients with cancerous solid tumors, blood disorders, and healthy HLA-compatible family members to better understand these diseases and improve treatments. This observational study collects biological samples to evaluate therapies, refine approaches, and explore prevention opportunities. Participants include those enrolled or being screened for treatment protocols at the NIH Clinical Center, as well as those receiving care through home health providers. The study collects blood, bone marrow, urine, stool, oral and nasopharyngeal samples, and tissue biopsies during routine medical care or research procedures. HLA-compatible donors may also provide white blood cells through leukapheresis, a process that separates white cells from blood. Samples are tracked, stored, analyzed, and used to study transplant effects and disease characteristics. Participants contribute samples during their medical visits or home care, with additional samples requested periodically. Assessments include collection of various biological specimens, with some procedures performed specifically for research. The main outcome is ongoing biospecimen storage. The study involves patients aged 2 years and older and may include healthy volunteers, with no set end date.

CONDITIONS

Brief Title

Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family Members

Who Can Participate

Age: 2Years - 100Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosis of malignant solid tumor or a malignant or non-malignant blood disorder, and being screened for eligibility for an NIH protocol
  • Diagnosis of malignant solid tumor or blood disorder, and already enrolled on a protocol at the NIH Clinical Center
  • Related HLA-compatible family member of a patient with malignant solid tumor or blood disorder being evaluated or treated at NIH, identified as a potential stem cell donor
  • Diagnosis of malignant solid tumor, blood disorder, or bone marrow failure condition, unable to participate in NIH protocol or travel to NIH, referred through home health care provider
  • Ability to understand the investigational nature of the study and provide informed consent or have a Legally Authorized Representative do so
  • Age 2 years and older (no upper limit)
Not Eligible

You will not qualify if you...

  • Unable to comprehend the investigational nature of the protocol or provide consent
  • Age less than 2 years

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Sample Collection

Duration - Ongoing throughout participation

Participants provide blood, bone marrow, urine, stool, oral, nasopharyngeal, and/or tissue samples for research purposes.

Visits occur as needed for sample collection depending on participant status and cohort

Trial Site Locations

Total: 1 location

1

National Institutes of Health Clinical Center

Bethesda, Maryland, United States, 20892

Actively Recruiting

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Research Team

B

Bretagne C Cowling, R.N.

R

Richard W Childs, M.D.

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Published Research Related To This Trial

Deep sequencing and flow cytometric characterization of expanded effector memory CD8+CD57+ T cells frequently reveals T-cell receptor Vβ oligoclonality and CDR3 homology in acquired aplastic anemia.

Valentina Giudice, Xingmin Feng, Zenghua Lin...

https://pubmed.ncbi.nlm.nih.gov/29419434