Actively Recruiting
Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family Members
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2026-05-01
6000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will collect biological samples for use in research experiments aimed at better understanding the clinical features of certain diseases. The specimens may be used to evaluate the effectiveness of known therapies, refine treatment approaches, identify potential new therapies, and explore opportunities for disease prevention. The following individuals 2 years of age or older may be eligible for this study: * Patients with a cancerous solid tumor or a cancerous or non-cancerous blood disorder who are being screened for or who are enrolled in a treatment study at the NIH Clinical Center * HLA-compatible donor family members (18 years of age or older) of the above patients who are being evaluated for or are enrolled in an NIH study as a stem cell transplant donor * Patients with a cancerous solid tumor or a cancerous or non-cancerous blood disorder or a bone marrow failure condition who cannot participate in an NIH treatment protocol or travel to the NIH Clinical Center and who are referred for participation through their home health care provider. Research samples will be collected from participants when blood is drawn or bone marrow, urine, or stool is collected, or tumor or other tissue is biopsied as part of their general medical care. Investigators may periodically request an additional sample of blood, stool, or urine. Participants who are 18 years of age or older may donate a large number of white blood cells through a procedure called leukapheresis. This procedure is not part of general medical care and would be done for research purposes only. For apheresis, a catheter (plastic tube) is placed in a vein in the subject's arm. Blood flows from the vein into a cell separator machine, where the white cells are separated from the red cells, platelets, and plasma by a spinning process. The white cells are removed and collected, and the rest of the blood is returned to the subject through a second tube placed in the other arm.
CONDITIONS
Official Title
Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family Members
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of malignant solid tumor or malignant or non-malignant blood disorder and being screened for an NIH protocol
- Diagnosis of malignant solid tumor or malignant or non-malignant blood disorder and already enrolled on an NIH Clinical Center protocol
- Related HLA-compatible family member of a patient with malignant solid tumor or blood disorder evaluated or enrolled at NIH, identified as potential stem cell donor
- Diagnosis of malignant solid tumor, blood disorder, or bone marrow failure condition and referred through home health care provider if unable to participate or travel to NIH
- Able to understand the investigational nature and provide informed consent or have a legally authorized representative
- Age 2 years or older
You will not qualify if you...
- Unable to understand the investigational nature of the study or provide informed consent
- Younger than 2 years old
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
B
Bretagne C Cowling, R.N.
CONTACT
R
Richard W Childs, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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