Study to Detect Alpha-Synuclein Protein in Colon Tissue During Routine Colonoscopy for People with Parkinsons Disease or REM Sleep Behavior Disorder

What this Trial Is About

Researchers are studying whether tissue samples taken from the colon during routine colonoscopies can detect signs of Parkinsons disease or REM Sleep Behavior Disorder RBD. The study focuses on finding a protein called phosphorylated alpha-synuclein in colon tissue, which may help diagnose these conditions earlier than current methods that rely on symptoms. Early detection could allow doctors to begin treatment sooner when the disease is less advanced. During the routine colonoscopy procedure, doctors will take four small additional tissue samples from the colon two from each side. This adds only about two minutes to the standard procedure. After the colonoscopy, no extra visits are needed. The collected tissue samples will be tested for the alpha-synuclein protein to evaluate its presence in participants with Parkinsons disease or RBD. Participants will undergo the usual colonoscopy as planned, with the extra tissue sampling included. No individual test results will be given to participants. Researchers will measure the presence of phosphorylated alpha-synuclein in the colon tissue at the time of the procedure. The study involves 40 adults aged 40 to 99 who have Parkinsons disease or RBD and who are already scheduled for routine colonoscopy. The study is sponsored by CND Life Sciences and aims to improve early diagnosis of these neurological conditions.

Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder