Actively Recruiting
Detection of Phosphorylated Alpha-Synuclein in Colon Tissue During Routine Colonoscopy for Parkinson's Disease or REM Sleep Behavior Disorder
Led by CND Life Sciences · Updated on 2026-02-11
40
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying whether tissue samples taken from the colon during routine colonoscopies can detect signs of Parkinson's disease or REM Sleep Behavior Disorder (RBD). The study focuses on finding a protein called phosphorylated alpha-synuclein in colon tissue, which may help diagnose these conditions earlier than current methods that rely on symptoms. Early detection could allow doctors to begin treatment sooner when the disease is less advanced. During the routine colonoscopy procedure, doctors will take four small additional tissue samples from the colon (two from each side). This adds only about two minutes to the standard procedure. After the colonoscopy, no extra visits are needed. The collected tissue samples will be tested for the alpha-synuclein protein to evaluate its presence in participants with Parkinson's disease or RBD. Participants will undergo the usual colonoscopy as planned, with the extra tissue sampling included. No individual test results will be given to participants. Researchers will measure the presence of phosphorylated alpha-synuclein in the colon tissue at the time of the procedure. The study involves 40 adults aged 40 to 99 who have Parkinson's disease or RBD and who are already scheduled for routine colonoscopy. The study is sponsored by CND Life Sciences and aims to improve early diagnosis of these neurological conditions.
CONDITIONS
Brief Title
Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 40 to 99 years
- Diagnosed with clinically confirmed Parkinson's disease or REM Sleep Behavior Disorder without diagnosis of Parkinson's Disease, dementia with Lewy bodies, or multiple system atrophy
- Scheduled to undergo a routine colonoscopy for screening, surveillance, or diagnostic purposes related to colon cancer or other gastrointestinal diseases
- Relatively healthy men and women
You will not qualify if you...
- Use of anticoagulants other than Plavix or aspirin
- Currently receiving active treatment for colon cancer (30-day post treatment allowed)
- Having an ongoing gastrointestinal illness
- Recent abdominal surgery
- Pregnant or planning pregnancy before the scheduled colonoscopy
- Significant cognitive impairment as determined by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of colonoscopy procedure
Participants undergo a routine colonoscopy during which additional small tissue samples from the colon are collected to test for a specific protein linked to Parkinson's disease and REM Sleep Behavior Disorder.
1 visit (in-person) during routine colonoscopy
Duration - No additional time commitment beyond colonoscopy day
Participants are observed after the colonoscopy with no additional visits required. Tissue samples will be analyzed for research purposes, but participants will not receive individual test results.
No additional visits
Trial Site Locations
Total: 1 location
1
Digestive Disease Associates
Branford, Connecticut, United States, 06405
Actively Recruiting
Research Team
C
Christina Wagner
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here