Actively Recruiting
Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder
Led by CND Life Sciences · Updated on 2026-02-11
40
Participants Needed
1
Research Sites
203 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to learn whether tissue samples taken from the colon during routine colonoscopy can detect signs of Parkinson's disease or REM Sleep Behavior Disorder (RBD). The main question it aims to answer is: Can doctors find a protein called alpha-synuclein in colon tissue samples from people with Parkinson's disease and RBD? Currently, Parkinson's disease is diagnosed by observing symptoms like tremors and movement problems and RBD by loss of muscle atonia during REM sleep, but by then the disease has already progressed significantly. Earlier detection could help doctors start treatment sooner.
CONDITIONS
Official Title
Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women aged 40 to 99 years
- Diagnosed with clinically confirmed Parkinson's disease or clinically confirmed REM Sleep Behavior Disorder without Parkinson's, dementia with Lewy bodies, or multiple system atrophy
- Scheduled to undergo a routine colonoscopy for colon cancer screening, surveillance, or diagnostic evaluation of gastrointestinal diseases
You will not qualify if you...
- Use of anticoagulants other than aspirin or Plavix
- Currently undergoing treatment for colon cancer or within 30 days post anti-cancer treatment
- Having active gastrointestinal illness
- Recent abdominal surgery
- Pregnant or planning pregnancy before the colonoscopy
- Significant cognitive impairment as determined by study investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Digestive Disease Associates
Branford, Connecticut, United States, 06405
Actively Recruiting
Research Team
C
Christina Wagner
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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