Actively Recruiting
Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
Led by Dartmouth-Hitchcock Medical Center · Updated on 2026-05-07
8946
Participants Needed
22
Research Sites
654 weeks
Total Duration
On this page
Sponsors
D
Dartmouth-Hitchcock Medical Center
Lead Sponsor
P
Patient-Centered Outcomes Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of colorectal polyps who are due for surveillance colonoscopy.
CONDITIONS
Official Title
Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
Who Can Participate
Eligibility Criteria
You may qualify if you...
- English or Spanish speaking
- Personal history of colorectal polyps
- Most recent colonoscopy with 2 or fewer non-advanced polyps
- Currently due or coming due within 12 months for colonoscopy
- Able to provide written informed consent
You will not qualify if you...
- Personal history of colorectal cancer
- Personal history of genetic syndrome with high risk for colorectal cancer (e.g. Lynch Syndrome, Familial Adenomatous Polyposis Syndrome, or Serrated Polyposis Syndrome)
- Personal history of inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease)
- Most recent colonoscopy with advanced polyp(s) or 3 or more non-advanced polyps
- Patients unlikely to benefit from polyp surveillance due to recent heart disease treatment, heart failure, lung disease requiring home oxygen, recent stroke, dementia affecting daily living activities, severe liver disease requiring medication, confusion or bleeding, severe kidney disease requiring dialysis, or a new cancer diagnosis within the last year
- Patients unable to provide written informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 22 locations
1
University of Alabama Birmingham
Birmingham, Alabama, United States, 35233
Active, Not Recruiting
2
University of Arizona
Tucson, Arizona, United States, 85719
Actively Recruiting
3
Jennifer Moreno Department of Veterans Affairs Medical Cneter
San Diego, California, United States, 92161
Actively Recruiting
4
Kaiser Permanente Northern California
Walnut Creek, California, United States, 94596
Actively Recruiting
5
University of Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
6
MedStar Health
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
7
James A. Haley Veterans Hospital
Tampa, Florida, United States, 33612-4745
Actively Recruiting
8
Northwestern Memorial Hospital
Chicago, Illinois, United States, 60611
Actively Recruiting
9
Richard L. Roudebush VA Medical Center
Indianapolis, Indiana, United States, 46202
Actively Recruiting
10
University of Michigan Health
Ann Arbor, Michigan, United States, 48105
Actively Recruiting
11
Henry Ford
Detroit, Michigan, United States, 48202
Actively Recruiting
12
Dartmouth Health
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
13
New York Harbor Health Care System - Dept of Veterans Affairs
New York, New York, United States, 10010
Actively Recruiting
14
Kaiser Permanente Northwest
Portand, Oregon, United States, 97232
Active, Not Recruiting
15
Oregon Health & Science University (Knight Cancer Institute)
Portland, Oregon, United States, 97239
Actively Recruiting
16
University of Utah
Salt Lake City, Utah, United States, 84112
Actively Recruiting
17
Intermountain Health
Sandy City, Utah, United States, 84094
Actively Recruiting
18
University of Virginia Health
Charlottesville, Virginia, United States, 22903
Actively Recruiting
19
University of Calgary
Calgary, Alberta, Canada, T2N 5A1
Actively Recruiting
20
University of British Columbia
Vancouver, British Columbia, Canada, V6Z 1Y6
Actively Recruiting
21
University of Manitoba
Winnipeg, Manitoba, Canada, R3EOW3
Actively Recruiting
22
London Health Sciences Centre Research Institute
London, Ontario, Canada, N6A 5W9
Actively Recruiting
Research Team
B
Barbie Patel, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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