Actively Recruiting
Color Change and Desensitization of Molar Incisor Hypomineralization-Affected Enamel Using Biomimetic Nano-Hydroxyapatite Toothpaste
Led by King Abdulaziz University · Updated on 2026-02-27
60
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial aims to evaluate if nano-hydroxyapatite (Nano-HA) toothpaste effectively treats children with Molar-Incisor Hypomineralization (MIH). It will also assess the safety of Nano-HA toothpaste. The main questions are: * Does Nano-HA toothpaste reduce caries incidence, improve tooth aesthetics, and decrease hypersensitivity? * How does Nano-HA compare to fluoridated toothpaste in terms of outcomes? Participants will: * Use Nano-HA or fluoridated toothpaste daily for 12 months. * Visit the clinic for checkups and evaluations every 1 to 3 months. * Record symptoms, brushing compliance, and sensitivity. The study will compare Nano-HA toothpaste to fluoridated toothpaste to determine its efficacy in managing MIH .
CONDITIONS
Official Title
Color Change and Desensitization of Molar Incisor Hypomineralization-Affected Enamel Using Biomimetic Nano-Hydroxyapatite Toothpaste
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 6-12 years
- Diagnosed with Molar-Incisor Hypomineralization (MIH) in at least one first permanent molar or hypomineralization of a second primary molar (HSPM)
- Presence of white, creamy, yellow, or brown demarcated opacities
- Indexed teeth include permanent first molars and permanent maxillary incisors
You will not qualify if you...
- Decayed permanent molars
- Diabetes, hypertension, sleeping disorders, or allergic reactions to medications
- Children on medication
- Presence of other enamel defects such as fluorosis, amelogenesis imperfecta, enamel hypoplasia, or white spot lesions
- Previous treatment with liquid enamel or other remineralizing agents on affected teeth
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
King Abdulaziz University Hospital, Jeddah, Saudi Arabia
Jeddah, Saudi Arabia
Actively Recruiting
Research Team
S
sabbagh
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here