Actively Recruiting
COlorectal BReath Analysis (COBRA2)
Led by Imperial College London · Updated on 2025-06-13
720
Participants Needed
5
Research Sites
218 weeks
Total Duration
On this page
Sponsors
I
Imperial College London
Lead Sponsor
N
National Institute for Health Research, United Kingdom
Collaborating Sponsor
AI-Summary
What this Trial Is About
Colorectal cancer (CRC) is the second most common cause of cancer death in the United Kingdom, with approximately 17,000 deaths per year. The five-year survival rate from CRC is only 10% when discovered at a late stage, but exceeds 90% if diagnosed early. Symptoms related to CRC can be non-specific, therefore the decision to refer for a colonoscopy can be challenging. There is a clear need to improve earlier detection of CRC so that patients with CRC can be identified earlier and faster, enabling them to start treatment more quickly. The study team is developing a non-invasive breath test that detects small molecules called volatile organic compounds (VOCs) that are specific to CRC. For patients with non-specific symptoms, this test would help GPs to identify those patients that may have underlying CRC, who would benefit from referral for specialised CRC tests.
CONDITIONS
Official Title
COlorectal BReath Analysis (COBRA2)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 2518 years or older referred from primary care with symptoms of suspected colorectal cancer.
- Patients with histologically confirmed colorectal adenocarcinoma (stages I-IV) who have not yet received treatment.
You will not qualify if you...
- Previous surgery altering the anatomy of the lower gastrointestinal tract, such as hemicolectomy or anterior resection.
- Previous treatment with chemotherapy, radiotherapy, or immunotherapy for colorectal cancer.
- Received bowel preparation for their colonoscopy procedure.
- History of any other cancer within the last three years.
- Unable or unwilling to provide informed written consent.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Chelsea and Westminster Hospital
London, United Kingdom
Actively Recruiting
2
Royal Marsden Hospital
London, United Kingdom
Active, Not Recruiting
3
St Mark's Hospital
London, United Kingdom
Active, Not Recruiting
4
St Mary's Hospital
London, United Kingdom
Actively Recruiting
5
West Middlesex University Hospital
London, United Kingdom
Actively Recruiting
Research Team
M
Mr Michael G Fadel, BSc MBBS MRCS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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