Actively Recruiting
Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed Resection Registry Study
Led by Northwestern University · Updated on 2026-02-10
80
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating different approved methods of liver transplantation in patients with unresectable liver metastases caused by colorectal cancer (CRLM). This study aims to compare clinical outcomes such as procedure results, hospital recovery, and survival rates one year after transplant. Blood samples will also be collected from participants for future research. All methods studied are standard procedures approved by the United Network of Organ Sharing (UNOS). Participants may undergo various liver transplant approaches, including living donor liver transplants using right or left lobe grafts, two-staged procedures involving partial donor grafts and delayed total hepatectomy, or whole liver transplants from deceased donors allocated by the MELD scoring system. The two-staged procedures involve initially removing part of the liver and transplanting a donor segment, followed by removing the remaining native liver once the transplant has grown sufficiently. During the study, investigators will monitor participants from the time of liver transplant through 12 months to assess graft and patient survival outcomes. They will also review detailed transplant recipient outcomes during this period. Participants will be observed for recovery progress, and blood samples will be collected to support ongoing research efforts. The total participation duration spans from transplant until one year afterward.
CONDITIONS
Brief Title
Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed Resection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients of any gender aged 18 years or older listed as liver transplant candidates at Northwestern with liver metastases due to colorectal cancer
- Ability to provide informed consent personally without a legally authorized representative
You will not qualify if you...
- Adults unable to provide informed consent
- Pregnant women
- Certain clinical, surgical, or anatomical conditions as determined by the principal investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Approximately 2 weeks until initial liver volume is sufficient
Participants undergo liver transplant procedures involving living or deceased donor grafts with staged hepatectomies.
1 to 2 in-person visits depending on surgical stage
Duration - Up to 12 months after transplant
Participants are monitored for graft and patient survival outcomes after liver transplant surgery.
Regular follow-up visits during 12 months post-transplant
Trial Site Locations
Total: 1 location
1
Northwestern University-Comprehensive Transplant Center
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
Y
Yajaira Navarro
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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