Actively Recruiting
Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF
Led by Third Affiliated Hospital, Sun Yat-Sen University · Updated on 2024-11-29
200
Participants Needed
1
Research Sites
210 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is to investigate investigate the safety and efficacy of Double plasma molecular adsorption system with sequential low-dose plasma exchange in treating hepatitis B virus-related acute-on-chronic liver failure.
CONDITIONS
Official Title
Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of chronic hepatitis B virus infection (positive hepatitis B surface antigen or positive hepatitis B virus DNA for more than 0.5 year)
- Age from 18 to 65 years old
- Clinical diagnosis of liver failure with serum total bilirubin level more than 10 times upper limit of normal; prothrombin time activity less than 40% and ≥20%, or prothrombin time international ratio between 1.5 and 2.6
- Platelet count greater than 50 x 10^9/L
You will not qualify if you...
- Presence of other active liver diseases
- Diagnosis of hepatocellular carcinoma or other cancers
- Pregnancy or lactation
- Infection with human immunodeficiency virus or congenital immune deficiency diseases
- Severe diabetes, autoimmune diseases, or unstable infarction due to cardio-cerebrovascular events
- Other important organ dysfunctions or previous organ transplantation
- Severe complications including severe infection, gastrointestinal bleeding, hepatic encephalopathy, or hepatorenal syndrome
- Inability to follow up for the study
- Investigator's judgment of participant unsuitability
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Third Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China, 510630
Actively Recruiting
Research Team
W
Wenxiong Xu, Doctor
CONTACT
L
Liang Peng, Doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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