Combination of Leukocyte Cell Surface Biomarkers to Differentiate Bacterial From Viral Infections in Emergency Departments: Multicenter Cohort Validation Study

What this Trial Is About

Researchers are studying how to quickly identify whether an infection is caused by bacteria or viruses using specific markers on white blood cells. This study focuses on patients visiting emergency departments with suspected infections in three hospitals in Paris. The goal is to confirm which combinations of these cell surface markers best distinguish bacterial from viral infections, using a large group of 500 patients, including data from a previous study. Participants will have two additional blood samples taken during their routine blood tests in the emergency room. These samples will be processed and frozen for later analysis with a special cytometer to measure the levels of several biomarkers on white blood cells. The study will use advanced computer methods to find the best marker combinations for diagnosis. There is no change to the usual care or treatment during the study. During their hospital stay, participants' clinical data, routine blood tests, and microbiology results will be recorded up to 28 days. Two independent experts will review all clinical and biological information (except the marker results) to classify the infection type and severity. The study will measure how well the marker combinations identify bacterial versus viral infections by comparing with this expert diagnosis, assessing sensitivity, specificity, and accuracy.

Combination of Leukocyte Cell Surface Biomarkers Measured by Cytometry, to Differentiate Bacterial From Viral Infections in Emergency Department: a Multicentric Cohort for the Validation of Diagnostic Performances