Actively Recruiting
Combination of NMDA-enhancing and Anti-inflammatory Treatments for Schizophrenia
Led by China Medical University Hospital · Updated on 2025-02-19
60
Participants Needed
1
Research Sites
320 weeks
Total Duration
On this page
Sponsors
C
China Medical University Hospital
Lead Sponsor
M
Ministry of Science and Technology, Taiwan
Collaborating Sponsor
AI-Summary
What this Trial Is About
Previous studies found that some NMDA-enhancing agents were able to improve clinical symptoms of patients with chronic schizophrenia. In addition, several drugs with anti-inflammatory properties have been tested in clinical trials for the treatment of schizophrenia too. Whether combined treatment of an NMDA-enhancing agent and a drug with anti-inflammatory property can be better than an NMDA-enhancing agent alone deserves study.
CONDITIONS
Official Title
Combination of NMDA-enhancing and Anti-inflammatory Treatments for Schizophrenia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a DSM-5 diagnosis of schizophrenia
- Are resistant to adequate treatments of at least two antipsychotics
- Remain symptomatic without clinically significant fluctuation, with unchanged antipsychotic doses for at least 3 months and during the 12-week trial
- PANSS total score 270
- Agree to participate in the study and provide informed consent
You will not qualify if you...
- DSM-5 diagnosis of intellectual disability or substance (including alcohol) use disorder
- History of epilepsy, head trauma, stroke, or serious medical or central nervous system diseases (other than schizophrenia) that may interfere with the study
- Clinically significant abnormal laboratory screening tests (including blood routine, biochemical tests)
- Pregnancy or lactation
- Inability to follow protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Psychiatry, China Medical University Hospital
Taichung, Taiwan
Actively Recruiting
Research Team
H
Hsien-Yuan Lane, M.D., Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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