Actively Recruiting
Combination of NMDA-enhancing and Antioxidant Treatments for Schizophrenia
Led by China Medical University Hospital · Updated on 2025-02-19
90
Participants Needed
1
Research Sites
326 weeks
Total Duration
On this page
Sponsors
C
China Medical University Hospital
Lead Sponsor
M
Ministry of Science and Technology, Taiwan
Collaborating Sponsor
AI-Summary
What this Trial Is About
Previous studies found that some NMDA-enhancing agents were able to improve clinical symptoms of patients with schizophrenia. In addition, several drugs with antioxidant properties have been tested in clinical trials for the treatment of schizophrenia too. Whether combined treatment of an NMDA-enhancing agent and a drug with antioxidant property can be better than an NMDA-enhancing agent alone deserves study.
CONDITIONS
Official Title
Combination of NMDA-enhancing and Antioxidant Treatments for Schizophrenia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a DSM-5 diagnosis of schizophrenia
- Remain symptomatic without clinically significant fluctuation
- Antipsychotic doses unchanged for at least 3 months and maintained during the 12-week trial
- PANSS total score 60
- Agree to participate and provide informed consent
You will not qualify if you...
- Diagnosis of intellectual disability or substance (including alcohol) use disorder
- History of epilepsy, head trauma, stroke, or serious medical or central nervous system diseases other than schizophrenia
- Clinically significant abnormal laboratory screening tests
- Pregnancy or lactation
- Inability to follow the study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Psychiatry, China Medical University Hospital
Taichung, Taiwan
Actively Recruiting
Research Team
H
Hsien-Yuan Lane, M.D., Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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