Shorter Combination Treatment of 5-Fluorouracil and Calcipotriol Versus Standard 5-Fluorouracil for Actinic Keratosis

What this Trial Is About

Researchers are evaluating treatments for actinic keratoses AK, a skin condition that can benefit from field-directed therapy. This study compares a new combination treatment of 5-fluorouracil 5FU and calcipotriol CAL against the standard 5FU therapy alone. The goal is to find out if a shorter treatment with 5FU-CAL can be as effective as the longer 5FU-only course, while reducing side effects like redness, itching, burning, and crusting that often lead to poor adherence and early treatment stopping. The study involves two treatment groups. One group will apply a combination of topical 5FU and CAL twice daily for 4 or 6 consecutive days, depending on the treatment location. The other group will use topical 5FU alone twice daily for 4 weeks. Treatment areas include the face, ears, scalp, neck, chest, and upper extremities. The study will carefully monitor how these treatments perform over time. Participants will be followed for 12 months after finishing treatment to assess treatment success. Researchers will measure clearance and recurrence of AK lesions, side effects, patient satisfaction, treatment compliance, and quality of life at multiple points before, during, and after treatment. This thorough follow-up aims to understand how well the shorter combination therapy works compared to the standard 4-week 5FU treatment.

Combination Therapy of 5-Fluorouracil and CALcipotriol Versus 5-Fluorouracil in the Treatment of Actinic Keratosis