Study of Combined Cognitive Rehabilitation and Exercise to Improve Learning and Memory in Adults With Moderate to Severe Traumatic Brain Injury

What this Trial Is About

This trial investigates new learning and memory impairment NLMI in people with moderate to severe traumatic brain injury TBI. The study evaluates whether combining aerobic exercise training AET with the Kessler Foundation modified Story Memory Technique KF-mSMT improves memory, brain function, and daily life outcomes better than KF-mSMT with stretching exercises. The goal is to find more effective ways to help individuals with TBI regain memory abilities and improve quality of life. Participants are randomly assigned to one of two groups one receiving KF-mSMT alongside supervised aerobic cycling, and the other receiving KF-mSMT with supervised stretching and toning exercises. Both interventions occur three days per week for 12 weeks, with the cognitive rehabilitation starting after the first 4 weeks of exercise. Each session starts at 15 minutes and gradually increases to 2 hours by the end of the program. During the study, participants will be regularly assessed using memory tests, brain MRI scans focusing on the hippocampus, and everyday memory simulations to measure progress. The primary outcome is change in verbal learning test performance over 12 weeks. Safety and adherence will be monitored while participants complete questionnaires and cognitive evaluations. The study lasts 12 weeks, with ongoing evaluation of how these combined treatments affect memory and brain health in TBI patients.

Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury