Actively Recruiting

Early Phase 1
Age: 18Years - 65Years
All Genders
Healthy Volunteers
NCT07017023

Combined Blood Pressure Medication and Activity Scheduling for Low Mood

Led by University of Oxford · Updated on 2025-07-24

76

Participants Needed

1

Research Sites

77 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This study explores the effects of 7-day losartan (50mg) versus placebo with brief behavioural activation on emotional processing in young volunteers low in positive mood

CONDITIONS

Official Title

Combined Blood Pressure Medication and Activity Scheduling for Low Mood

Who Can Participate

Age: 18Years - 65Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Willing and able to provide informed consent
  • Aged 18-65 years
  • Self-reported low levels of positive mood
  • Sufficient written and spoken English skills to understand study procedures
  • Normal or corrected to normal vision and hearing
  • Access to a computer and reliable internet connection
Not Eligible

You will not qualify if you...

  • Antidepressant treatment or medication in last three months
  • Currently receiving cognitive-behavioural therapy with behavioural activation
  • History of psychosis or bipolar disorder
  • History of substance dependence
  • Use of illegal drugs in last 3 months
  • First-degree relative with history of psychosis or bipolar disorder
  • Current or past hospitalisation for mental health reasons
  • BDI-II score >30
  • Judged to be currently at clinical risk of suicide
  • Past suicide attempt
  • CNS-medication last 6 weeks (including in another study)
  • Severely underweight or overweight in a manner that renders them unsuitable for the study in the opinion of the study medic
  • Current blood pressure or other heart medication
  • Diagnosis of intravascular fluid depletion or dehydration
  • History of angioedema
  • Impaired kidney function (based on self-report)
  • Very low blood pressure following established definitions (at least three consecutive measurements of blood pressure under standardised conditions where either the systolic or the diastolic blood pressure or both are below 90/60 mmHg)
  • Current diagnosis of a developmental disorder (e.g. ADHD, Tourette's syndrome, severe learning disability) according to self-report, where such difficulties would likely interfere with compliance or task performance
  • Current diagnosis of a neurological disorder (e.g. epilepsy, MS) according to self-report
  • Lifetime history of systemic infection, or clinically significant hepatic, cardiac, obstructive respiratory, renal, cerebrovascular, metabolic, endocrine or pulmonary disease or disorder which may put the participant at risk or influence compliance or task performance
  • Pregnancy, breastfeeding or plans to become pregnant during study participation
  • Heavy use of cigarettes (smoking more than 20 cigarettes per day)
  • Severe lactose intolerance (due to losartan containing some lactose monohydrate)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Warneford Hospital, University of Oxford

Oxford, Oxfordshire, United Kingdom, OX37JX

Actively Recruiting

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Research Team

A

Andrea Reinecke, PhD

CONTACT

R

Rowan Haslam, MSc

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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