Effects of Losartan Combined with Behavioural Activation on Emotional Processing in Adults with Low Positive Mood

What this Trial Is About

Researchers are studying the effects of combining a blood pressure medication called losartan with behavioural activation therapy on people aged 18 to 65 who have low positive mood. Behavioural Activation BA helps improve mood by encouraging involvement in rewarding activities, but those with low positive mood often respond less well. This study aims to see if adding losartan, which may improve how positive information is processed in the brain, can enhance the benefits of BA in these individuals. Participants will be randomly assigned to receive either 7 days of losartan 50mg oral tablets with behavioural activation or 7 days of placebo capsules with behavioural activation. Both groups will undergo daily behavioural activation activities for 7 days while taking the assigned medication. The study is double-blinded, meaning neither participants nor researchers know who receives losartan or placebo during the intervention period. During the study, participants will complete computer tasks before and after the 7-day treatment to measure how they process positive and negative information. Researchers will assess changes in learning, social approach decisions, and motivation. The study includes regular monitoring of participants health and mood. Total participation lasts about one week of active treatment with assessments before and after this period.

Combined Blood Pressure Medication and Activity Scheduling for Low Mood