Actively Recruiting
Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia
Led by Sunnybrook Health Sciences Centre · Updated on 2025-12-12
12
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
Sponsors
S
Sunnybrook Health Sciences Centre
Lead Sponsor
A
Alzheimer Society of Canada
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study evaluates whether the combined treatment of methylphenidate and non-invasive brain stimulation, called intermittent theta burst stimulation, can effectively treat apathy in individuals with Alzheimer's disease or mixed AD/vascular dementia
CONDITIONS
Official Title
Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Alzheimer's disease or mixed Alzheimer's and vascular disease
- Mini-Mental State Examination (MMSE) score between 10 and 28 inclusive
- Presence of clinically significant apathy
- Stable dose of psychotropic medication
- Care partner spends at least 10 hours per week with the participant
You will not qualify if you...
- Current major depressive episode
- Clinically significant agitation, delusions, or hallucinations
- Taking dopaminergic agents other than methylphenidate
- Not passing the TMS adult safety scale (e.g., having unapproved pacemakers, metallic implants, or history of epilepsy)
- Central nervous system abnormalities other than Alzheimer's disease considered clinically significant
- History of seizures
- Any condition making participation medically unsafe according to the study physician
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sunnybrook Research Institute
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NA
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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