National Pilot Project on Combined First Trimester Screening for Pregnancy Complications and Congenital Defects in Czech Republic

What this Trial Is About

Researchers are conducting a national, prospective, multicenter pilot project in the Czech Republic to establish a standardized combined first trimester screening for pregnant women. This screening aims to predict and detect serious obstetric complications such as preeclampsia, fetal growth restriction, preterm labor, intrauterine fetal demise, and structural congenital defects, including chromosomal abnormalities. The study seeks to create a unified method for performing and evaluating this screening linked with the National Health Information System to improve care quality and accessibility. The screening process includes collecting maternal, ultrasound, biochemical, and biophysical parameters during the first trimester of pregnancy 11th-13th week. Certified software from the Fetal Medicine Foundation will be used to assess individual risks for preeclampsia, fetal growth restriction, and fetal chromosomal aneuploidies like trisomies 21, 18, and 13. The project plans to test this methodology on a sample of 2000 women and aims to support the development of reimbursement mechanisms from public health insurance. Participants will be involved during the first trimester, providing data for analysis and risk assessment. The study will measure the proportion of women identified with increased risk for the targeted conditions from June 2025 to October 2026. Women must consent to participate and allow processing of personal data. This observational study is supported by national and European funds and strives to enhance pregnancy care outcomes for all population groups, including socially excluded communities.

The Combined First Trimester Screening