Actively Recruiting
Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty: A Randomized Controlled Trial
Led by Kafrelsheikh University · Updated on 2025-02-21
75
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effect of combining intrathecal dexmedetomidine with an adductor canal block to manage pain after total knee arthroplasty (TKA). This study aims to improve postoperative pain control, helping patients recover faster and reduce complications. The study focuses on analgesia after knee surgery, involving adults aged 18 to 75 years with specific health criteria. Participants are randomly assigned to one of three groups: one receiving intrathecal dexmedetomidine with bupivacaine and a saline adductor canal block, another receiving bupivacaine intrathecally with an active bupivacaine adductor canal block, and a third group receiving both intrathecal dexmedetomidine and an active bupivacaine adductor canal block. All treatments are given at the end of surgery under spinal anesthesia. During the study, researchers will monitor total morphine use and pain levels for 48 hours after surgery, as well as heart rate and blood pressure in the first hour after anesthesia. Patient satisfaction and any side effects will also be assessed. The study uses a double-blind design and measures outcomes to better understand pain relief methods after knee replacement surgery.
CONDITIONS
Brief Title
Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age from 18 to 75 years.
- Both sexes.
- American Society of Anesthesiology (ASA) physical status I-II.
- Scheduled for total knee arthroplasty under spinal anesthesia.
You will not qualify if you...
- Patients with neurological or intellectual disability.
- History of allergy to local anesthetics or dexmedetomidine.
- Infection at the injection site.
- Prolonged use of analgesic or sedative medications.
- Coagulation abnormalities.
- Pregnancy.
- Obesity [body mass index (BMI) > 30 kg/m2].
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgery day and immediate postoperative period
Participants receive spinal anesthesia with either intrathecal dexmedetomidine, adductor canal block, or a combination of both at the end of knee surgery for pain management.
1 surgical and anesthesia visit
Duration - 48 hours postoperatively
Participants are monitored for pain control, vital signs, and adverse events during the first 48 hours after surgery.
Approximately 3 visits within 48 hours postoperatively
Trial Site Locations
Total: 1 location
1
Kafrelsheikh University
Kafr ash Shaykh, Kafrelsheikh, Egypt, 33516
Actively Recruiting
Research Team
S
Sherif K Arafa, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here